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Review
. 2022 Jan;25(1):3-13.
doi: 10.22038/IJBMS.2021.59604.13226.

MicroRNA-96: A therapeutic and diagnostic tumor marker

Hamid Reza Rahimi  1 , Majid Mojarrad  1 , Meysam Moghbeli  1
Affiliations
Review

MicroRNA-96: A therapeutic and diagnostic tumor marker

Hamid Reza Rahimi et al. Iran J Basic Med Sci. 2022 Jan.

Abstract

Cancer has been always considered as one of the main human health challenges worldwide. One of the main causes of cancer-related mortality is late diagnosis in the advanced stages of the disease, which reduces the therapeutic efficiency. Therefore, novel non-invasive diagnostic methods are required for the early detection of tumors and improving the quality of life and survival in cancer patients. MicroRNAs (miRNAs) have pivotal roles in various cellular processes such as cell proliferation, motility, and neoplastic transformation. Since circulating miRNAs have high stability in body fluids, they can be suggested as efficient noninvasive tumor markers. MiR-96 belongs to the miR-183-96-182 cluster that regulates cell migration and tumor progression as an oncogene or tumor suppressor by targeting various genes in solid tumors. In the present review, we have summarized all of the studies that assessed the role of miR-96 during tumor progression. This review clarifies the molecular mechanisms and target genes recruited by miR-96 to regulate tumor progression and metastasis. It was observed that miR-96 mainly affects tumorigenesis by targeting the structural proteins and FOXO transcription factors.

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Conflict of interest statement

The authors declare that they have no conflicts of interest.

Figures

Figure 1
Figure 1
All of the molecular mechanisms and interactions of miR-96 during tumor initiation, progression, and metastasis
Figure 2
Figure 2
Role of miR-96 in regulation of structural proteins during tumor progressions
Figure 3
Figure 3
MiR-96 is involved in tumor progression and invasion through regulation of the WNT signaling pathway
See this image and copyright information in PMC

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