Circulating extracellular vesicles and tumor cells: sticky partners in metastasis
- PMID: 35644773
- DOI: 10.1016/j.trecan.2022.05.002
Circulating extracellular vesicles and tumor cells: sticky partners in metastasis
Abstract
The intravascular behavior of tumor-derived extracellular vesicles (EVs) and circulating tumor cells (CTCs) lies at the heart of the metastatic cascade. Their capacity to disseminate and stop at specific vascular regions precedes and determines the formation of metastatic foci. We discuss in detail the central role of cellular adhesion molecules (CAMs) that are present on EV/CTC surface, as well as their endothelial ligands, in dictating their arrest site and their capacity to exit the vasculature. We focus on the differences and similarities between CAMs on CTCs and EVs, and speculate about their role in the organotropism of different cancer types. Better understanding of the binding mechanisms might pinpoint potential targets for novel therapies.
Keywords: cancer cell extravasation; cell adhesion; circulating tumor cells; endothelium; extracellular vesicles; metastasis.
Copyright © 2022 Elsevier Inc. All rights reserved.
Conflict of interest statement
Declaration of interests The authors declare no conflicts of interest.
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