The Legend of ATP: From Origin of Life to Precision Medicine

doi:10.3390/metabo12050461

Review

. 2022 May 20;12(5):461.

doi: 10.3390/metabo12050461.

The Legend of ATP: From Origin of Life to Precision Medicine

Xin-Yi Chu^{1

2}, Yuan-Yuan Xu¹, Xin-Yu Tong¹, Gang Wang¹, Hong-Yu Zhang¹

Affiliations

¹ Hubei Key Laboratory of Agricultural Bioinformatics, College of Informatics, Huazhong Agricultural University, Wuhan 430070, China.
² Qian Xuesen Collaborative Research Center of Astrochemistry and Space Life Sciences, Institute of Drug Discovery Technology, Ningbo University, Ningbo 315211, China.

PMID: 35629965
PMCID: PMC9148104
DOI: 10.3390/metabo12050461

Review

The Legend of ATP: From Origin of Life to Precision Medicine

Xin-Yi Chu et al. Metabolites. 2022.

. 2022 May 20;12(5):461.

doi: 10.3390/metabo12050461.

Authors

Xin-Yi Chu^{1

2}, Yuan-Yuan Xu¹, Xin-Yu Tong¹, Gang Wang¹, Hong-Yu Zhang¹

Affiliations

¹ Hubei Key Laboratory of Agricultural Bioinformatics, College of Informatics, Huazhong Agricultural University, Wuhan 430070, China.
² Qian Xuesen Collaborative Research Center of Astrochemistry and Space Life Sciences, Institute of Drug Discovery Technology, Ningbo University, Ningbo 315211, China.

PMID: 35629965
PMCID: PMC9148104
DOI: 10.3390/metabo12050461

Abstract

Adenosine triphosphate (ATP) may be the most important biological small molecule. Since it was discovered in 1929, ATP has been regarded as life's energy reservoir. However, this compound means more to life. Its legend starts at the dawn of life and lasts to this day. ATP must be the basic component of ancient ribozymes and may facilitate the origin of structured proteins. In the existing organisms, ATP continues to construct ribonucleic acid (RNA) and work as a protein cofactor. ATP also functions as a biological hydrotrope, which may keep macromolecules soluble in the primitive environment and can regulate phase separation in modern cells. These functions are involved in the pathogenesis of aging-related diseases and breast cancer, providing clues to discovering anti-aging agents and precision medicine tactics for breast cancer.

Keywords: adenosine triphosphate (ATP); drug discovery; hydrotrope; origin of life; phase separation; precision medicine.

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Conflict of interest statement

The authors declare no conflict of interest.

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References

1. Sharov A.A. Coenzyme autocatalytic network on the surface of oil microspheres as a model for the origin of life. Int. J. Mol. Sci. 2009;10:1838–1852. doi: 10.3390/ijms10041838. - DOI - PMC - PubMed
1. Sharov A.A. Coenzyme world model of the origin of life. Biosystems. 2016;144:8–17. doi: 10.1016/j.biosystems.2016.03.003. - DOI - PMC - PubMed
1. Beis I., Newsholme E.A. The contents of adenine nucleotides, phosphagens and some glycolytic intermediates in resting muscles from vertebrates and invertebrates. Biochem. J. 1975;152:23–32. doi: 10.1042/bj1520023. - DOI - PMC - PubMed
1. Langen P., Hucho F. Karl Lohmann and the discovery of ATP. Angew. Chem. Int. Ed. Engl. 2008;47:1824–1827. doi: 10.1002/anie.200702929. - DOI - PubMed
1. Jewell J.B., Sowders J.M., He R., Willis M.A., Gang D.R., Tanaka K. Extracellular ATP shapes a defense–related transcriptome both independently and along with other defense signaling pathways. Plant Physiol. 2019;179:1144–1158. doi: 10.1104/pp.18.01301. - DOI - PMC - PubMed

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[1] Sharov A.A. Coenzyme autocatalytic network on the surface of oil microspheres as a model for the origin of life. Int. J. Mol. Sci. 2009;10:1838–1852. doi: 10.3390/ijms10041838. - DOI - PMC - PubMed

[2] Sharov A.A. Coenzyme autocatalytic network on the surface of oil microspheres as a model for the origin of life. Int. J. Mol. Sci. 2009;10:1838–1852. doi: 10.3390/ijms10041838. - DOI - PMC - PubMed

[3] Sharov A.A. Coenzyme world model of the origin of life. Biosystems. 2016;144:8–17. doi: 10.1016/j.biosystems.2016.03.003. - DOI - PMC - PubMed

[4] Sharov A.A. Coenzyme world model of the origin of life. Biosystems. 2016;144:8–17. doi: 10.1016/j.biosystems.2016.03.003. - DOI - PMC - PubMed

[5] Beis I., Newsholme E.A. The contents of adenine nucleotides, phosphagens and some glycolytic intermediates in resting muscles from vertebrates and invertebrates. Biochem. J. 1975;152:23–32. doi: 10.1042/bj1520023. - DOI - PMC - PubMed

[6] Beis I., Newsholme E.A. The contents of adenine nucleotides, phosphagens and some glycolytic intermediates in resting muscles from vertebrates and invertebrates. Biochem. J. 1975;152:23–32. doi: 10.1042/bj1520023. - DOI - PMC - PubMed

[7] Langen P., Hucho F. Karl Lohmann and the discovery of ATP. Angew. Chem. Int. Ed. Engl. 2008;47:1824–1827. doi: 10.1002/anie.200702929. - DOI - PubMed

[8] Langen P., Hucho F. Karl Lohmann and the discovery of ATP. Angew. Chem. Int. Ed. Engl. 2008;47:1824–1827. doi: 10.1002/anie.200702929. - DOI - PubMed

[9] Jewell J.B., Sowders J.M., He R., Willis M.A., Gang D.R., Tanaka K. Extracellular ATP shapes a defense–related transcriptome both independently and along with other defense signaling pathways. Plant Physiol. 2019;179:1144–1158. doi: 10.1104/pp.18.01301. - DOI - PMC - PubMed

[10] Jewell J.B., Sowders J.M., He R., Willis M.A., Gang D.R., Tanaka K. Extracellular ATP shapes a defense–related transcriptome both independently and along with other defense signaling pathways. Plant Physiol. 2019;179:1144–1158. doi: 10.1104/pp.18.01301. - DOI - PMC - PubMed

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The Legend of ATP: From Origin of Life to Precision Medicine

Affiliations

The Legend of ATP: From Origin of Life to Precision Medicine

Authors

Affiliations

Abstract

Conflict of interest statement

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