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Review
. 2022 Apr 19;9(5):196.
doi: 10.3390/vetsci9050196.

Treatment of Canine Oral Melanomas: A Critical Review of the Literature

Paolo Pazzi  1 , Gerhard Steenkamp  1 , Anouska J Rixon  1
Affiliations
Review

Treatment of Canine Oral Melanomas: A Critical Review of the Literature

Paolo Pazzi et al. Vet Sci. .

Abstract

Critical appraisal of the available literature for the treatment of canine oral malignant melanoma (OMM) is lacking. This critical review aimed to evaluate the current literature and provide treatment recommendations and possible suggestions for future canine OMM research. PubMed, Web of Science and Google Scholar were searched in June 2021, for terms relevant to treatment of OMM. Inclusion and exclusion criteria were applied and information on clinical response and outcome extracted. Eighty-one studies were included. The overall level of evidence supporting the various canine OMM treatment options was low. The majority of studies included confounding treatment modalities and lacked randomization, control groups and consistency in reporting clinical response and outcomes. Within these limitations, surgery remains the mainstay of therapy. Adjunctive radiotherapy provided good local control and improved median survival times (MST), chemotherapy did not offer survival benefit beyond that of surgery, while electrochemotherapy may offer a potential alternative to radiotherapy. Immunotherapy holds the most promise in extending MST in the surgical adjunctive setting, in particular the combination of gene therapy and autologous vaccination. Prospective, randomized, double-blinded clinical trials, with a lack of confounding factors and reporting based on established guidelines would allow comparison and recommendations for the treatment of canine OMM.

Keywords: chemotherapy; dog; immunotherapy; melanoma; oral; radiotherapy; surgery.

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Conflict of interest statement

The authors declare no conflict of interest.

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References

    1. Nishiya A.T., Massoco C.O., Felizzola C.R., Perlmann E., Batschinski K., Tedardi M.V., Garcia J.S., Mendonça P.P., Teixeira T.F., Zaidan Dagli M.L. Comparative Aspects of Canine Melanoma. Vet. Sci. 2016;3:7. doi: 10.3390/vetsci3010007. - DOI - PMC - PubMed
    1. Wingo K. Histopathologic Diagnoses from Biopsies of the Oral Cavity in 403 Dogs and 73 Cats. J. Vet. Dent. 2018;35:7–17. doi: 10.1177/0898756418759760. - DOI - PubMed
    1. Todoroff R.J., Brodey R.S. Oral and pharyngeal neoplasia in the dog: A retrospective survey of 361 cases. J. Am. Vet. Med. Assoc. 1979;175:567–571. - PubMed
    1. Gorlin R.J., Barron C.N., Chaudhry A.P., Clark J.J. The oral and pharyngeal pathology of domestic animals: A study of 487 cases. Am. J. Vet. Res. 1959;20:1032–1061.
    1. Brodey R. A clinical and pathological study of 130 neoplasms of the mouth and pharynx in the dog. Am. J. Vet. Res. 1960;21:787–812.

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