Nanoformulation of Plant-Based Natural Products for Type 2 Diabetes Mellitus: From Formulation Design to Therapeutic Applications
- PMID: 35586563
- PMCID: PMC9108891
- DOI: 10.1016/j.curtheres.2022.100672
Nanoformulation of Plant-Based Natural Products for Type 2 Diabetes Mellitus: From Formulation Design to Therapeutic Applications
Abstract
Background: Herbal remedies are used to manage type 2 diabetes mellitus (type 2 DM) as the sole treatment or as a complementary therapy. Limitations of herbal remedies, such as poor stability and limited absorption, impede their development as therapeutic agents, which could be overcome by nanoformulations.
Objectives: This review attempts to summarize the studies reported between 2009 and 2020 in the development of medicinal plant-based nanoformulations for the management of type 2 DM, discuss formulation methods, mechanisms of action, and identify gaps in the literature to conduct future research on nanoparticle-based herbal treatment options targeting type 2 DM.
Methods: To retrieve articles published between January 2009 and December 2020, the electronic databases PubMed, Science Direct, and Google Scholar were searched with the keywords nanoparticle, plant, and diabetes in the entire text. Peer-reviewed research articles on herbal nanoformulations published in English-language based on in vitro and/or in vivo models of type 2 DM and/or its complications were included. The literature search and selection of titles/abstracts were carried out independently by 2 authors. The list of full-text articles was selected considering inclusion and exclusion criteria, with the agreement of all the authors.
Results: Among the reported studies, 68% of the studies were on inorganic herbal nanoformulations, whereas 17% and 8% were of polymer-based and lipid-based herbal nanoformulations, respectively. Some of the important biological properties of nanoformulations included improvement in glycemic control and insulin levels, inhibition of the formation of advanced glycation end products, and regeneration of pancreatic β cells. The aforementioned properties were observed by screening nanoformulations using in vitro cellular and noncellular models, as well as in vivo animal models of type 2 DM studied for acute or subacute durations. Only 2 clinical trials with patients with diabetes were reported, indicating the need for further research on medicinal plant-based nanoformulations as a therapeutic option for the management of type 2 DM.
Conclusions: Medicinal plant extracts and isolated compounds have been nanoformulated using various methods. The properties of the nanoformulations were found superior to those of the corresponding herbal extracts and isolated compounds. At both the preclinical and clinical levels, there are a number of poorly explored research areas in the development and bioactivity assessment of herbal nanoformulations. (Curr Ther Res Clin Exp. 2022; 83:XXX-XXX) © 2022 Elsevier HS Journals, Inc.
Keywords: herbal remedies; inorganic nanoformulations; lipid-based nanoformulations; polymeric nanoformulations; type 2 diabetes mellitus.
© 2022 Published by Elsevier Inc.
Figures
Similar articles
-
Herbal Nanoformulations for Diabetes: Mechanisms, Formulations, and Clinical Impact.Curr Diabetes Rev. 2024 Mar 18. doi: 10.2174/0115733998288592240308073925. Online ahead of print. Curr Diabetes Rev. 2024. PMID: 38500279
-
Beyond the black stump: rapid reviews of health research issues affecting regional, rural and remote Australia.Med J Aust. 2020 Dec;213 Suppl 11:S3-S32.e1. doi: 10.5694/mja2.50881. Med J Aust. 2020. PMID: 33314144
-
Data-driven modeling and prediction of blood glucose dynamics: Machine learning applications in type 1 diabetes.Artif Intell Med. 2019 Jul;98:109-134. doi: 10.1016/j.artmed.2019.07.007. Epub 2019 Jul 26. Artif Intell Med. 2019. PMID: 31383477 Review.
-
FreeStyle Libre Flash Glucose Self-Monitoring System: A Single-Technology Assessment [Internet].Oslo, Norway: Knowledge Centre for the Health Services at The Norwegian Institute of Public Health (NIPH); 2017 Aug 21. Report from the Norwegian Institute of Public Health No. 2017-07. Oslo, Norway: Knowledge Centre for the Health Services at The Norwegian Institute of Public Health (NIPH); 2017 Aug 21. Report from the Norwegian Institute of Public Health No. 2017-07. PMID: 29553668 Free Books & Documents. Review.
-
Herbal Medicines Targeting the Improved β-Cell Functions and β-Cell Regeneration for the Management of Diabetes Mellitus.Evid Based Complement Alternat Med. 2021 Jul 14;2021:2920530. doi: 10.1155/2021/2920530. eCollection 2021. Evid Based Complement Alternat Med. 2021. PMID: 34335803 Free PMC article. Review.
Cited by
-
Development of chitosan lipid nanoparticles to alleviate the pharmacological activity of piperine in the management of cognitive deficit in diabetic rats.Sci Rep. 2024 Apr 8;14(1):8247. doi: 10.1038/s41598-024-58601-x. Sci Rep. 2024. PMID: 38589438 Free PMC article.
-
In-vitro and ex-vivo antidiabetic, and antioxidant activities of Box-Behnken design optimized Solanum xanthocarpum extract loaded niosomes.Saudi Pharm J. 2023 Oct;31(10):101785. doi: 10.1016/j.jsps.2023.101785. Epub 2023 Sep 14. Saudi Pharm J. 2023. PMID: 37766819 Free PMC article.
-
Nanosuspension of Foeniculum Vulgare Promotes Accelerated Sensory and Motor Function Recovery after Sciatic Nerve Injury.Metabolites. 2023 Mar 7;13(3):391. doi: 10.3390/metabo13030391. Metabolites. 2023. PMID: 36984831 Free PMC article.
-
A review on phytochemical and pharmacological facets of tropical ethnomedicinal plants as reformed DPP-IV inhibitors to regulate incretin activity.Front Endocrinol (Lausanne). 2022 Nov 11;13:1027237. doi: 10.3389/fendo.2022.1027237. eCollection 2022. Front Endocrinol (Lausanne). 2022. PMID: 36440220 Free PMC article. Review.
-
Central Composite Design (CCD) for the Optimisation of Ethosomal Gel Formulation of Punica granatum Extract: In Vitro and In Vivo Evaluations.Gels. 2022 Aug 17;8(8):511. doi: 10.3390/gels8080511. Gels. 2022. PMID: 36005111 Free PMC article.
References
-
- International Diabetes Federation . ninth ed. 2019. IDF Diabetes Atlas. Brussels, Belgium.
-
- World Health Organization, Noncommunicable Diseases Country Profiles 2018, https://apps.who.int/iris/handle/10665/274512.
-
- American Diabetes Association, 2. Classification and diagnosis of diabetes: Standards of medical care in diabetes. Diabetes Care. 2020;43:S14–S31. - PubMed
-
- LeRoith D. Beta- cell dysfunction and insulin resistance in type 2 diabetes: role of metabolic and genetic abnormalities. Am J Med Sci. 2002;113:3–11. - PubMed
Publication types
LinkOut - more resources
Full Text Sources