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Review
. 2022 Apr 29:13:894508.
doi: 10.3389/fimmu.2022.894508. eCollection 2022.

The Yin and Yang of Targeting KLRG1+ Tregs and Effector Cells

Samantha M Borys  1 , Arup K Bag  2 , Laurent Brossay  1 , Dennis O Adeegbe  2
Affiliations
Review

The Yin and Yang of Targeting KLRG1+ Tregs and Effector Cells

Samantha M Borys et al. Front Immunol. .

Abstract

The literature surrounding KLRG1 has primarily focused on NK and CD8+ T cells. However, there is evidence that the most suppressive Tregs express KLRG1. Until now, the role of KLRG1 on Tregs has been mostly overlooked and remains to be elucidated. Here we review the current literature on KLRG1 with an emphasis on the KLRG1+ Treg subset role during cancer development and autoimmunity. KLRG1 has been recently proposed as a new checkpoint inhibitor target, but these studies focused on the effects of KLRG1 blockade on effector cells. We propose that when designing anti-tumor therapies targeting KLRG1, the effects on both effector cells and Tregs will have to be considered.

Keywords: KLRG1; Treg targeting; cancer; immune modulation; regulatory T cells (T reg).

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Targeting KLRG1 differentially on effector cells and Treg cells may benefit the host during cancer immunotherapy. Functions of KLRG1 signaling on various effector cells as well as Tregs are summarized. Figure was created on BioRender.
See this image and copyright information in PMC

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