Gelatin methacryloyl (GelMA)-based biomaterials for bone regeneration

doi:10.1039/c9ra02695a

Review

. 2019 Jun 5;9(31):17737-17744.

doi: 10.1039/c9ra02695a. eCollection 2019 Jun 4.

Gelatin methacryloyl (GelMA)-based biomaterials for bone regeneration

Zhenqiang Dong¹, Qijuan Yuan², Keqing Huang², Wanli Xu¹, Guiting Liu², Zhipeng Gu^{2

3}

Affiliations

¹ Department of Chemistry and Material Engineering, Quzhou University Quzhou 324000 P. R. China.
² Key Laboratory of Sensing Technology and Biomedical Instrument of Guangdong Province, School of Biomedical Engineering, Sun Yat-sen University Guangzhou 510006 P. R. China guzhp@mail.sysu.edu.cn liugt3@mail.sysu.edu.cn.
³ Research Institute of Sun Yat-sen University in Shenzhen Shenzhen 518057 PR China.

PMID: 35520570
PMCID: PMC9064644
DOI: 10.1039/c9ra02695a

Review

Gelatin methacryloyl (GelMA)-based biomaterials for bone regeneration

Zhenqiang Dong et al. RSC Adv. 2019.

. 2019 Jun 5;9(31):17737-17744.

doi: 10.1039/c9ra02695a. eCollection 2019 Jun 4.

Authors

Zhenqiang Dong¹, Qijuan Yuan², Keqing Huang², Wanli Xu¹, Guiting Liu², Zhipeng Gu^{2

3}

Affiliations

¹ Department of Chemistry and Material Engineering, Quzhou University Quzhou 324000 P. R. China.
² Key Laboratory of Sensing Technology and Biomedical Instrument of Guangdong Province, School of Biomedical Engineering, Sun Yat-sen University Guangzhou 510006 P. R. China guzhp@mail.sysu.edu.cn liugt3@mail.sysu.edu.cn.
³ Research Institute of Sun Yat-sen University in Shenzhen Shenzhen 518057 PR China.

PMID: 35520570
PMCID: PMC9064644
DOI: 10.1039/c9ra02695a

Abstract

Gelatin methacryloyl (GelMA)-based biomaterials have been widely used in various biomedical applications due to their suitable biological properties and tuneable physical characteristics. In particular, GelMA can be used as a versatile matrix for bone tissue engineering scaffolds via various strategies to overcome major obstacles such as insufficient mechanical property and uncontrollable degradation. This review presents the research status of GelMA, its structure and function, GelMA-based biomaterials and the development of methods along with their existing challenges.

This journal is © The Royal Society of Chemistry.

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Conflict of interest statement

There are no conflicts to declare.

Figures

**Fig. 1. Schematic of GelMA and the fabrication of its hydrogels.**

**Fig. 2. Fabrication of the bone mimetic 3D architecture using the 3D bioprinted method to construct a bone-like unite architecture.**

**Fig. 3. Fabrication of the bone mimetic 3D architecture using the micromachining method to construct osteogenic and vasculogenic niches.**

**Fig. 4. The application of the micromachining method for the engineering of hydrogels to create 3D vascularized bone tissues.**

See this image and copyright information in PMC

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References

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[1] Zheng Y. Huang K. You X. Huang B. Wu J. Gu Z. Int. J. Biol. Macromol. 2017;104:1143–1149. doi: 10.1016/j.ijbiomac.2017.07.017. - DOI - PubMed

[2] Zheng Y. Huang K. You X. Huang B. Wu J. Gu Z. Int. J. Biol. Macromol. 2017;104:1143–1149. doi: 10.1016/j.ijbiomac.2017.07.017. - DOI - PubMed

[3] Hao Z. Song Z. Huang J. Huang K. Panetta A. Gu Z. Wu J. Biomater. Sci. 2017;5:1382–1392. doi: 10.1039/C7BM00146K. - DOI - PubMed

[4] Hao Z. Song Z. Huang J. Huang K. Panetta A. Gu Z. Wu J. Biomater. Sci. 2017;5:1382–1392. doi: 10.1039/C7BM00146K. - DOI - PubMed

[5] Almubarak S. Nethercott H. Freeberg M. Beaudon C. Jha A. Jackson W. Marcucio R. Miclau T. Healy K. Bahney C. Bone. 2016;83:197–209. doi: 10.1016/j.bone.2015.11.011. - DOI - PMC - PubMed

[6] Almubarak S. Nethercott H. Freeberg M. Beaudon C. Jha A. Jackson W. Marcucio R. Miclau T. Healy K. Bahney C. Bone. 2016;83:197–209. doi: 10.1016/j.bone.2015.11.011. - DOI - PMC - PubMed

[7] Gu Z. Xie H. Li L. Zhang X. Liu F. Yu X. J. Mater. Sci.: Mater. Med. 2013;24:1251–1260. doi: 10.1007/s10856-013-4891-8. - DOI - PubMed

[8] Gu Z. Xie H. Li L. Zhang X. Liu F. Yu X. J. Mater. Sci.: Mater. Med. 2013;24:1251–1260. doi: 10.1007/s10856-013-4891-8. - DOI - PubMed

[9] Bose S. Roy M. Bandyopadhyay A. Trends Biotechnol. 2012;30:546–554. doi: 10.1016/j.tibtech.2012.07.005. - DOI - PMC - PubMed

[10] Bose S. Roy M. Bandyopadhyay A. Trends Biotechnol. 2012;30:546–554. doi: 10.1016/j.tibtech.2012.07.005. - DOI - PMC - PubMed

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Gelatin methacryloyl (GelMA)-based biomaterials for bone regeneration

Affiliations

Gelatin methacryloyl (GelMA)-based biomaterials for bone regeneration

Authors

Affiliations

Abstract

Conflict of interest statement

Figures

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