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Review
. 2022 Aug;1869(8):119277.
doi: 10.1016/j.bbamcr.2022.119277. Epub 2022 Apr 25.

The pivotal role of FAM134B in selective ER-phagy and diseases

Wei Chen  1 , Hui Mao  1 , Linxi Chen  2 , Lanfang Li  3
Affiliations
Free article
Review

The pivotal role of FAM134B in selective ER-phagy and diseases

Wei Chen et al. Biochim Biophys Acta Mol Cell Res. 2022 Aug.
Free article

Abstract

FAM134B is also known as the reticulophagy regulator 1 (RETREG1) or JK-1. FAM134B consists of two long hydrophobic fragments with a reticulon-homology domain, an N-terminal cytoplasmic domain, and a C-terminal cytoplasmic domain. FAM134B plays an important role in regulating selective ER-phagy, and is related to the occurrence and development of many diseases. In the present review, we describe theFAM134B molecular structure, subcellular localization, tissue distribution, and review its mechanisms of action during selective ER-phagy. Furthermore, we summarize the relationship between FAM134B and diseases, including neoplastic diseases, degenerative diseases, central nervous system disease, and infectious diseases. Considering the pleiotropic action of FAM134B, targeting FAM134B may be a potent therapeutic avenue for these diseases.

Keywords: Cancer; ER-phagy; FAM134B; HSAN II B; Vascular dementia; Viral diseases.

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