Biomimetic approaches for targeting tumor-promoting inflammation

doi:10.1016/j.semcancer.2022.04.007

Review

. 2022 Nov;86(Pt 2):555-567.

doi: 10.1016/j.semcancer.2022.04.007. Epub 2022 Apr 25.

Biomimetic approaches for targeting tumor-promoting inflammation

Alessandro Parodi¹, Dmitry Kostyushev², Sergey Brezgin², Anastasiya Kostyusheva³, Tatiana Borodina⁴, Roman Akasov⁵, Anastasia Frolova¹, Vladimir Chulanov², Andrey A Zamyatnin Jr⁶

Affiliations

¹ Scientific Center for Genetics and Life Sciences, Division of Biotechnology, Sirius University of Science and Technology, 354340 Sochi, Russia; Institute of Molecular Medicine, Sechenov First Moscow State Medical University, 119991 Moscow, Russia.
² Scientific Center for Genetics and Life Sciences, Division of Biotechnology, Sirius University of Science and Technology, 354340 Sochi, Russia; National Medical Research Center of Tuberculosis and Infectious Diseases, Ministry of Health, 127994 Moscow, Russia; Infectious Diseases Depaertment, Sechenov First Moscow State Medical University, 119991 Moscow, Russia.
³ National Medical Research Center of Tuberculosis and Infectious Diseases, Ministry of Health, 127994 Moscow, Russia; Infectious Diseases Depaertment, Sechenov First Moscow State Medical University, 119991 Moscow, Russia.
⁴ Scientific Center for Genetics and Life Sciences, Division of Biotechnology, Sirius University of Science and Technology, 354340 Sochi, Russia; Federal Scientific Research Centre "Crystallography and Photonics" of Russian Academy of Sciences, 119333 Moscow, Russia.
⁵ Institute of Molecular Medicine, Sechenov First Moscow State Medical University, 119991 Moscow, Russia; Federal Scientific Research Centre "Crystallography and Photonics" of Russian Academy of Sciences, 119333 Moscow, Russia.
⁶ Scientific Center for Genetics and Life Sciences, Division of Biotechnology, Sirius University of Science and Technology, 354340 Sochi, Russia; Institute of Molecular Medicine, Sechenov First Moscow State Medical University, 119991 Moscow, Russia; Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, 119992 Moscow, Russia; Faculty of Health and Medical Sciences, University of Surrey, Guildford UK GU2 7X, United Kingdom. Electronic address: zamyat@belozersky.msu.ru.

PMID: 35472397
DOI: 10.1016/j.semcancer.2022.04.007

Review

Biomimetic approaches for targeting tumor-promoting inflammation

Alessandro Parodi et al. Semin Cancer Biol. 2022 Nov.

. 2022 Nov;86(Pt 2):555-567.

doi: 10.1016/j.semcancer.2022.04.007. Epub 2022 Apr 25.

Authors

Alessandro Parodi¹, Dmitry Kostyushev², Sergey Brezgin², Anastasiya Kostyusheva³, Tatiana Borodina⁴, Roman Akasov⁵, Anastasia Frolova¹, Vladimir Chulanov², Andrey A Zamyatnin Jr⁶

Affiliations

¹ Scientific Center for Genetics and Life Sciences, Division of Biotechnology, Sirius University of Science and Technology, 354340 Sochi, Russia; Institute of Molecular Medicine, Sechenov First Moscow State Medical University, 119991 Moscow, Russia.
² Scientific Center for Genetics and Life Sciences, Division of Biotechnology, Sirius University of Science and Technology, 354340 Sochi, Russia; National Medical Research Center of Tuberculosis and Infectious Diseases, Ministry of Health, 127994 Moscow, Russia; Infectious Diseases Depaertment, Sechenov First Moscow State Medical University, 119991 Moscow, Russia.
³ National Medical Research Center of Tuberculosis and Infectious Diseases, Ministry of Health, 127994 Moscow, Russia; Infectious Diseases Depaertment, Sechenov First Moscow State Medical University, 119991 Moscow, Russia.
⁴ Scientific Center for Genetics and Life Sciences, Division of Biotechnology, Sirius University of Science and Technology, 354340 Sochi, Russia; Federal Scientific Research Centre "Crystallography and Photonics" of Russian Academy of Sciences, 119333 Moscow, Russia.
⁵ Institute of Molecular Medicine, Sechenov First Moscow State Medical University, 119991 Moscow, Russia; Federal Scientific Research Centre "Crystallography and Photonics" of Russian Academy of Sciences, 119333 Moscow, Russia.
⁶ Scientific Center for Genetics and Life Sciences, Division of Biotechnology, Sirius University of Science and Technology, 354340 Sochi, Russia; Institute of Molecular Medicine, Sechenov First Moscow State Medical University, 119991 Moscow, Russia; Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, 119992 Moscow, Russia; Faculty of Health and Medical Sciences, University of Surrey, Guildford UK GU2 7X, United Kingdom. Electronic address: zamyat@belozersky.msu.ru.

PMID: 35472397
DOI: 10.1016/j.semcancer.2022.04.007

Abstract

With the ultimate goal of increasing tumor accumulation of therapeutics, various nanocarriers have been designed to overcome biological barriers encountered at each stage, from drug administration to the cancerous lesion. Stabilizing circulation and functionalization of the targeting surface impart high tumor accumulation properties to nanocarriers. However, various cells can recognize and infiltrate the tumor microenvironment more efficiently than synthetic carriers via overexpression of adhesive ligands, particularly in inflamed stroma of tumors. Thus, a new field of nanomedicine, called biomimicry, has evolved to generate nanoparticles with the same biological characteristics as cells that naturally infiltrate tumors. Revolutionary synthetic processes have been developed to transfer the cell membrane of leukocytes and mesenchymal cells to synthetic carriers. In addition, cells can generate their own "nanocarriers," known as exosomes, to transport molecular messages to distant sites, while biomimicry of viral and bacterial agents allows high targeting efficiency towards inflammatory immune cells. Alterations in the protein expression in cancer cells caused by inflammation can also be exploited for drug delivery. Finally, new developments in biomimetic drug delivery focus on turning the infiltrating cells into microcarriers that can actively perfuse the tumor and eventually release their therapeutic payload. In this review, we summarize recent developments in biomimetic drug delivery with a particular focus on targeting the tumor inflammatory microenvironment.

Keywords: Biomimicry; Drug delivery; Nanomedicine; Tumor inflammation.

PubMed Disclaimer

Cited by

Engineered photoresponsive biohybrids for tumor therapy.
Wang X, Sun Y, Wangpraseurt D. Wang X, et al. Smart Med. 2023 Mar 10;2(2):e20220041. doi: 10.1002/SMMD.20220041. eCollection 2023 May. Smart Med. 2023. PMID: 39188274 Free PMC article. Review.
Swelling, Rupture and Endosomal Escape of Biological Nanoparticles Per Se and Those Fused with Liposomes in Acidic Environment.
Ponomareva N, Brezgin S, Karandashov I, Kostyusheva A, Demina P, Slatinskaya O, Bayurova E, Silachev D, Pokrovsky VS, Gegechkori V, Khaydukov E, Maksimov G, Frolova A, Gordeychuk I, Zamyatnin AA Jr, Chulanov V, Parodi A, Kostyushev D. Ponomareva N, et al. Pharmaceutics. 2024 May 16;16(5):667. doi: 10.3390/pharmaceutics16050667. Pharmaceutics. 2024. PMID: 38794330 Free PMC article.
Physiologically Based Pharmacokinetic Modeling of Nanoparticle Biodistribution: A Review of Existing Models, Simulation Software, and Data Analysis Tools.
Kutumova EO, Akberdin IR, Kiselev IN, Sharipov RN, Egorova VS, Syrocheva AO, Parodi A, Zamyatnin AA Jr, Kolpakov FA. Kutumova EO, et al. Int J Mol Sci. 2022 Oct 19;23(20):12560. doi: 10.3390/ijms232012560. Int J Mol Sci. 2022. PMID: 36293410 Free PMC article. Review.
Proteolytic Resistance Determines Albumin Nanoparticle Drug Delivery Properties and Increases Cathepsin B, D, and G Expression.
Kolesova EP, Egorova VS, Syrocheva AO, Frolova AS, Kostyushev D, Kostyusheva A, Brezgin S, Trushina DB, Fatkhutdinova L, Zyuzin M, Demina PA, Khaydukov EV, Zamyatnin AA Jr, Parodi A. Kolesova EP, et al. Int J Mol Sci. 2023 Jun 16;24(12):10245. doi: 10.3390/ijms241210245. Int J Mol Sci. 2023. PMID: 37373389 Free PMC article.
Physiologically based pharmacokinetic model for predicting the biodistribution of albumin nanoparticles after induction and recovery from acute lung injury.
Kutumova EO, Akberdin IR, Egorova VS, Kolesova EP, Parodi A, Pokrovsky VS, Zamyatnin AA Jr, Kolpakov FA. Kutumova EO, et al. Heliyon. 2024 May 10;10(10):e30962. doi: 10.1016/j.heliyon.2024.e30962. eCollection 2024 May 30. Heliyon. 2024. PMID: 38803942 Free PMC article.

See all "Cited by" articles

Publication types

Actions
Actions

MeSH terms

Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions

Substances

Actions

LinkOut - more resources

Full Text Sources
- ClinicalKey
- Elsevier Science

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

Biomimetic approaches for targeting tumor-promoting inflammation

Affiliations

Biomimetic approaches for targeting tumor-promoting inflammation

Authors

Affiliations

Abstract

Similar articles

Cited by

Publication types

MeSH terms

Substances

LinkOut - more resources

Full Text Sources