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Review
. 2022 Apr 10;23(8):4170.
doi: 10.3390/ijms23084170.

Anti-Inflammatory and Antiviral Effects of Cannabinoids in Inhibiting and Preventing SARS-CoV-2 Infection

Marcin Janecki  1 , Michał Graczyk  2 , Agata Anna Lewandowska  3 , Łukasz Pawlak  4
Affiliations
Review

Anti-Inflammatory and Antiviral Effects of Cannabinoids in Inhibiting and Preventing SARS-CoV-2 Infection

Marcin Janecki et al. Int J Mol Sci. .

Abstract

The COVID-19 pandemic caused by the SARS-CoV-2 virus made it necessary to search for new options for both causal treatment and mitigation of its symptoms. Scientists and researchers around the world are constantly looking for the best therapeutic options. These difficult circumstances have also spurred the re-examination of the potential of natural substances contained in Cannabis sativa L. Cannabinoids, apart from CB1 and CB2 receptors, may act multifacetedly through a number of other receptors, such as the GPR55, TRPV1, PPARs, 5-HT1A, adenosine and glycine receptors. The complex anti-inflammatory and antiviral effects of cannabinoids have been confirmed by interactions with various signaling pathways. Considering the fact that the SARS-CoV-2 virus causes excessive immune response and triggers an inflammatory cascade, and that cannabinoids have the ability to regulate these processes, it can be assumed that they have potential to be used in the treatment of COVID-19. During the pandemic, there were many publications on the subject of COVID-19, which indicate the potential impact of cannabinoids not only on the course of the disease, but also their role in prevention. It is worth noting that the anti-inflammatory and antiviral potential are shown not only by well-known cannabinoids, such as cannabidiol (CBD), but also secondary cannabinoids, such as cannabigerolic acid (CBGA) and terpenes, emphasizing the role of all of the plant's compounds and the entourage effect. This article presents a narrative review of the current knowledge in this area available in the PubMed, Scopus and Web of Science medical databases.

Keywords: CBD; COVID-19; Cannabis sativa; SARS-CoV-2; anti-inflammatory; antiviral; cannabinoids; terpene.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Anti-inflammatory, immunological and antioxidative modes of action of cannabinoids [3].
See this image and copyright information in PMC

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References

    1. Gatta-Cherifi B., Cota D. New insights on the role of the endocannabinoid system in the regulation of energy balance. Int. J. Obes. 2016;40:210–219. doi: 10.1038/ijo.2015.179. - DOI - PubMed
    1. Di Marzo V. The endocannabinoid system: Its general strategy of action, tools for its pharmacological manipulation and potential therapeutic exploitation. Pharmacol. Res. 2009;60:77–84. doi: 10.1016/j.phrs.2009.02.010. - DOI - PubMed
    1. Graczyk M., Lewandowska A.A., Dzierżanowski T. The Therapeutic Potential of Cannabis in Counteracting Oxidative Stress and Inflammation. Molecules. 2021;26:4551. doi: 10.3390/molecules26154551. - DOI - PMC - PubMed
    1. Kendall D.A., Yudowski G.A. Cannabinoid receptors in the central nervous system: Their signaling and roles in disease. Front. Cell Neurosci. 2017;10:294. doi: 10.3389/fncel.2016.00294. - DOI - PMC - PubMed
    1. Raj V., Park J.G., Cho K.-H., Choi P., Kim T., Ham J., Lee J. Assessment of antiviral potencies of cannabinoids against SARS-CoV-2 using computational and in vitro approaches. Int. J. Biol. Macromol. 2021;168:474–485. doi: 10.1016/j.ijbiomac.2020.12.020. - DOI - PMC - PubMed

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