Neutrophil Functional Heterogeneity and Implications for Viral Infections and Treatments
- PMID: 35456003
- PMCID: PMC9025666
- DOI: 10.3390/cells11081322
Neutrophil Functional Heterogeneity and Implications for Viral Infections and Treatments
Abstract
Evidence suggests that neutrophils exert specialized effector functions during infection and inflammation, and that these cells can affect the duration, severity, and outcome of the infection. These functions are related to variations in phenotypes that have implications in immunoregulation during viral infections. Although the complexity of the heterogeneity of neutrophils is still in the process of being uncovered, evidence indicates that they display phenotypes and functions that can assist in viral clearance or augment and amplify the immunopathology of viruses. Therefore, deciphering and understanding neutrophil subsets and their polarization in viral infections is of importance. In this review, the different phenotypes of neutrophils and the roles they play in viral infections are discussed. We also examine the possible ways to target neutrophil subsets during viral infections as potential anti-viral treatments.
Keywords: heterogeneity; neutrophil; plasticity; subsets; viral infection.
Conflict of interest statement
The authors declare no conflict of interest.
Figures
Similar articles
-
Neutrophil subsets and their differential roles in viral respiratory diseases.J Leukoc Biol. 2022 Jun;111(6):1159-1173. doi: 10.1002/JLB.1MR1221-345R. Epub 2022 Jan 18. J Leukoc Biol. 2022. PMID: 35040189 Free PMC article. Review.
-
Neutrophil heterogeneity: Bona fide subsets or polarization states?J Leukoc Biol. 2018 May;103(5):829-838. doi: 10.1002/JLB.3RI0917-361R. Epub 2018 Feb 20. J Leukoc Biol. 2018. PMID: 29462505 Review.
-
Neutrophil heterogeneity in health and disease: a revitalized avenue in inflammation and immunity.Open Biol. 2012 Nov;2(11):120134. doi: 10.1098/rsob.120134. Open Biol. 2012. PMID: 23226600 Free PMC article. Review.
-
Update on Neutrophil Function in Severe Inflammation.Front Immunol. 2018 Oct 2;9:2171. doi: 10.3389/fimmu.2018.02171. eCollection 2018. Front Immunol. 2018. PMID: 30356867 Free PMC article. Review.
-
Neutrophil Recruitment and Participation in Severe Diseases Caused by Flavivirus Infection.Life (Basel). 2021 Jul 20;11(7):717. doi: 10.3390/life11070717. Life (Basel). 2021. PMID: 34357089 Free PMC article. Review.
Cited by
-
Neutrophils during SARS-CoV-2 infection: Friend or foe?Immunol Rev. 2023 Mar;314(1):399-412. doi: 10.1111/imr.13175. Epub 2022 Nov 28. Immunol Rev. 2023. PMID: 36440642 Free PMC article. Review.
-
The Role of Neutrophils in Biomaterial-Based Tissue Repair-Shifting Paradigms.J Funct Biomater. 2023 Jun 19;14(6):327. doi: 10.3390/jfb14060327. J Funct Biomater. 2023. PMID: 37367291 Free PMC article. Review.
-
High-Density Lipoproteins in Non-Cardiovascular Diseases.Int J Mol Sci. 2022 Aug 20;23(16):9413. doi: 10.3390/ijms23169413. Int J Mol Sci. 2022. PMID: 36012681 Free PMC article.
-
Appendectomy Mitigates Coxsackievirus B3-Induced Viral Myocarditis.Viruses. 2023 Sep 22;15(10):1974. doi: 10.3390/v15101974. Viruses. 2023. PMID: 37896753 Free PMC article.
-
Induction of protective immune responses at respiratory mucosal sites.Hum Vaccin Immunother. 2024 Dec 31;20(1):2368288. doi: 10.1080/21645515.2024.2368288. Epub 2024 Jul 2. Hum Vaccin Immunother. 2024. PMID: 38953250 Free PMC article. Review.
References
-
- Stegelmeier A.A., Chan L., Mehrani Y., Petrik J.J., Wootton S.K., Bridle B., Karimi K. Characterization of the Impact of Oncolytic Vesicular Stomatitis Virus on the Trafficking, Phenotype, and Antigen Presentation Potential of Neutrophils and Their Ability to Acquire a Non-Structural Viral Protein. Int. J. Mol. Sci. 2020;22:6347. doi: 10.3390/ijms21176347. - DOI - PMC - PubMed
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Medical