Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2022 Apr 21;18(4):e1010422.
doi: 10.1371/journal.ppat.1010422. eCollection 2022 Apr.

Exploitation of the Mediator complex by viruses

Affiliations

Exploitation of the Mediator complex by viruses

Joel Rovnak et al. PLoS Pathog. .
No abstract available

PubMed Disclaimer

Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Fig 1
Fig 1. Viral proteins target the Mediator complex to control viral and host gene expression.
Viral proteins known to bind to or associate with Mediator proteins in the tail, middle, and head and CDK modules are depicted. Ad, adenovirus E1A; BUNV, Bunyamwera virus NSs; CDK8, cyclin-dependent kinase 8; DENV, dengue virus NS5; HPV, human papilloma virus E7; HSV, herpes simplex virus VP16; KSHV, Kaposi sarcoma–associated herpesvirus Lana-1; RSV, respiratory syncytial virus NS1; RV-cyclin, retroviral cyclin; VZV, varicella zoster virus IE62; WDSV, Walleye dermal sarcoma virus. Created with BioRender.com.

Similar articles

Cited by

References

    1. Sadowski I, Ma J, Triezenberg S, Ptashne M. GAL4-VP16 is an unusually potent transcriptional activator. Nature. 1988;335(6190):563–4. doi: 10.1038/335563a0 - DOI - PubMed
    1. Kristie TM, LeBowitz JH, Sharp PA. The octamer-binding proteins form multi-protein—DNA complexes with the HSV alpha TIF regulatory protein. EMBO J. 1989;8(13):4229–38. - PMC - PubMed
    1. Triezenberg SJ, Kingsbury RC, McKnight SL. Functional dissection of VP16, the trans-activator of herpes simplex virus immediate early gene expression. Genes Dev. 1988;2(6):718–29. doi: 10.1101/gad.2.6.718 - DOI - PubMed
    1. Lahue EE, Smith AV, Orr-Weaver TL. A novel cyclin gene from Drosophila complements CLN function in yeast. Genes Dev. 1991;5:2166–75. doi: 10.1101/gad.5.12a.2166 - DOI - PubMed
    1. Leopold P, O’Farrell PH. An evolutionarily conserved cyclin homolog from Drosophila rescues yeast deficient in G1 cyclins. Cell. 1991;66:1207–16. doi: 10.1016/0092-8674(91)90043-x - DOI - PMC - PubMed

Publication types

Substances

Grants and funding

This work was supported in part by NIH R01CA95056 (SLQ) and a Colorado State University College of Veterinary Medicine and Biomedical Sciences College Research Council Grant (SLQ). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.