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. 2022 Mar 26;10(9):2700-2709.
doi: 10.12998/wjcc.v10.i9.2700.

Associations between coagulation factor XII, coagulation factor XI, and stability of venous thromboembolism: A case-control study

Yan Meng  1 , You Li  1 , Yan-Jun Ye  2 , Qiang Ma  1 , Jun-Bo Zhang  1 , Hao Qin  1 , Yang-Yang Deng  1 , Hong-Yan Tian  3
Affiliations

Associations between coagulation factor XII, coagulation factor XI, and stability of venous thromboembolism: A case-control study

Yan Meng et al. World J Clin Cases. .

Abstract

Background: Pulmonary embolism (PE) is a fatal clinical syndrome that is generally caused by an embolus from unstable deep venous thrombosis (DVT). However, clinical and biochemical factors that are related to the stability of DVT are not fully understood.

Aim: To evaluate the relationships between plasma antigen levels of factor XII (FXII:Ag) and factor XI (FXI:Ag) with the stability of DVT.

Methods: Patients with DVT and no PE, DVT and PE, and controls with no DVT or PE that matched for age, gender, and comorbidities were included in this study. FXII:Ag and FXI:Ag in peripheral venous blood were measured using enzyme-linked immunosorbent assays.

Results: Using the 95th percentile of FXI:Ag in patients with DVT and PE as the cut-off, a higher FXI:Ag was associated with a higher risk of unstable DVT (odds ratio: 3.15, 95% confidence interval: 1.18-8.43, P = 0.019). Stratified analyses showed consistent results in patients ≤ 60 years (P = 0.020), but not in those > 60 years (P = 0.346).

Conclusion: Higher plasma FXI:Ag might be a marker for unstable DVT, which might be associated with PE in these patients.

Keywords: Case-control study; Deep venous thrombosis; Factor XI; Factor XII; Pulmonary embolism.

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Conflict of interest statement

Conflict-of-interest statement: The authors declare that they have no potential conflicts of interest.

Figures

Figure 1
Figure 1
Factor XII antigen and factor XI antigen levels in patients with deep venous thrombosis, deep venous thrombosis and pulmonary embolism, and control groups. A: The dots represent the levels of factor XII antigen for each participant; B: The dots represent the levels of factor XI antigen for each participant. FXII:Ag: Factor XII antigen; FXI:Ag: Factor XI antigen; DVT: Deep venous thrombosis; PE: Pulmonary embolism.
See this image and copyright information in PMC

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