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Review
. 2022 Mar 5:96:100665.
doi: 10.1016/j.curtheres.2022.100665. eCollection 2022.

Stem Cell Therapy for Thyroid Diseases: Progress and Challenges

Sunyi Ye  1 , Zhu Lixian Zhu  1
Affiliations
Review

Stem Cell Therapy for Thyroid Diseases: Progress and Challenges

Sunyi Ye et al. Curr Ther Res Clin Exp. .

Abstract

Background: Thyroid hormones are indispensable for organ development and maintaining homeostasis. Thyroid diseases, including thyroiditis and thyroid cancer, affect the normal secretion of hormones and result in thyroid dysfunction.

Objective: This review focuses on therapeutic applications of stem cells for thyroid diseases.

Methods: A literature search of Medline and PubMed was conducted (January 2000-July 2021) to identify recent reports on stem cell therapy for thyroid diseases.

Results: Stem cells are partially developed cell types. They have the capacity to form specialized cells. Besides embryonic stem cells and mesenchymal stem cells, organ resident stem cells and cancer stem cells are recently reported to have important roles in forming organ specific cells and cancers. Stem cells, especially mesenchymal stem cells, have anti-inflammatory and anticancer functions as well.

Conclusions: This review outlines the therapeutic potency of embryonic stem cells, mesenchymal stem cells, thyroid resident stem cells, and thyroid cancer stem cells in thyroid cells' regeneration, thyroid function modulation, thyroiditis suppression, and antithyroid cancers. Stem cells represent a promising form of treatment for thyroid disorders.

Keywords: Autoimmune thyroid disorder; Stem cells; Thyroid diseases; Thyroid dysfunction.

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Figures

Figure 1
Figure 1
Functions of thyroid follicular cells and parafollicular cells. Ca = calcium ion; cAMP = cyclic adenosine monophosphate.
Figure 2
Figure 2
Molecular markers express on thyroid mature cells, thyroid precursor/stem cells, and thyroid cancer stem cells. They share some markers. CSC = cancer stem cells.
Figure 3
Figure 3
The roles of stem cells in the treatment of thyroid diseases. 3D = xxxxx (three dimensions); ESC = embryonic stem cells; iPS = induced pluripotent stem cells; MSC = mesenchymal stem cells; RSC = resident stem cells; TSH = thyroid stimulating hormone.
See this image and copyright information in PMC

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References

    1. Delitala AP, Capobianco G, Cherchi PL, Dessole S, Delitala G. Thyroid function and thyroid disorders during pregnancy: a review and care pathway. Archives of gynecology and obstetrics. 2019;299:327–338. - PubMed
    1. Cabanillas ME, McFadden DG, Durante C. Thyroid cancer. Lancet. 2016;388:2783–2795. - PubMed
    1. Nagayama Y. Thyroid Autoimmunity and Thyroid Cancer - The Pathogenic Connection: A 2018 Update. 2018;50:922-31. - PubMed
    1. Glicksman MA. Induced Pluripotent Stem Cells: The Most Versatile Source for Stem Cell Therapy. Clinical therapeutics. 2018;40:1060–1065. - PubMed
    1. Dunn A, Talovic M, Patel K, Patel A, Marcinczyk M, Garg K. Biomaterial and stem cell-based strategies for skeletal muscle regeneration. Journal of orthopaedic research: official publication of the Orthopaedic Research Society. 2019;37:1246–1262. - PubMed

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