Review
doi: 10.1126/sciimmunol.abo7799.
Epub 2022 Apr 1.
Epstein-Barr virus as a driver of multiple sclerosis
Affiliations
- PMID: 35363541
- DOI: 10.1126/sciimmunol.abo7799
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Review
Epstein-Barr virus as a driver of multiple sclerosis
Sci Immunol.
2022 Apr.
Abstract
Accumulating evidence implicates Epstein-Barr virus (EBV) as an etiological factor in multiple sclerosis (MS). If EBV is a "driver" that causes antiviral immunity with associated autoimmune components rather than a "trigger" that unleashes self-perpetuating autoimmunity, then elimination of EBV would be a rational therapy for MS.
Comment on
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Longitudinal analysis reveals high prevalence of Epstein-Barr virus associated with multiple sclerosis.Science. 2022 Jan 21;375(6578):296-301. doi: 10.1126/science.abj8222. Epub 2022 Jan 13. Science. 2022. PMID: 35025605
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