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. 2023 May;29(4):1565-1578.
doi: 10.1111/odi.14196. Epub 2022 Apr 8.

Risk factors for head and neck cancer in more and less developed countries: Analysis from the INHANCE consortium

Neerav Goyal  1 , Max Hennessy  1 , Erik Lehman  1 , Wenxue Lin  1 , Antonio Agudo  2 , Wolfgang Ahrens  3 , Stefania Boccia  4   5 , Paul Brennan  6 , Hermann Brenner  7   8   9 , Gabriella Cadoni  10   11 , Cristina Canova  12 , Chu Chen  13 , David Conway  14 , Maria Paula Curado  15 , Luigino Dal Maso  16 , Alexander W Daudt  17 , Valeria Edefonti  18 , Eleonora Fabianova  19 , Leticia Fernandez  20 , Silvia Franceschi  6 , Werner Garavello  21 , Maura Gillison  22 , Richard B Hayes  23 , Claire Healy  24 , Rolando Herrero  6 , Ivana Holcatova  25 , Jossy L Kanda  26 , Karl Kelsey  27 , Bo T Hansen  28 , Rosalina Koifman  29 , Pagona Lagiou  30 , Carlo La Vecchia  18 , Fabio Levi  31 , Guojun Li  32 , Jolanta Lissowska  33 , Rossana Mendoza López  34 , Danièle Luce  35 , Gary Macfarlane  36 , Dana Mates  37 , Keitaro Matsuo  38 , Michael McClean  39 , Ana Menezes  40 , Gwenn Menvielle  41 , Hal Morgenstern  42 , Kirsten Moysich  43 , Eva Negri  44 , Andrew F Olshan  45 , Tamas Pandics  46 , Jerry Polesel  16 , Mark Purdue  47 , Loredana Radoi  48 , Heribert Ramroth  49 , Lorenzo Richiardi  50 , Stimson Schantz  47 , Stephen M Schwartz  13 , Diego Serraino  16 , Oxana Shangina  51 , Elaine Smith  52 , Erich M Sturgis  53 , Beata Świątkowska  54 , Peter Thomson  55 , Thomas L Vaughan  13 , Marta Vilensky  56 , Deborah M Winn  57 , Victor Wunsch-Filho  58 , Guo-Pei Yu  59 , Jose P Zevallos  60 , Zuo-Feng Zhang  61 , Tongzhang Zheng  62 , Ariana Znaor  6 , Paolo Boffetta  63   64 , Mia Hashibe  65 , Yuan-Chin A Lee  65 , Joshua E Muscat  1
Affiliations
Free article

Risk factors for head and neck cancer in more and less developed countries: Analysis from the INHANCE consortium

Neerav Goyal et al. Oral Dis. 2023 May.
Free article

Abstract

Objective: We analyzed the pooled case-control data from the International Head and Neck Cancer Epidemiology (INHANCE) consortium to compare cigarette smoking and alcohol consumption risk factors for head and neck cancer between less developed and more developed countries.

Subjects and methods: The location of each study was categorized as either a less developed or more developed country. We compared the risk of overall head and neck cancer and cancer of specific anatomic subsites associated with cigarette smoking and alcohol consumption. Additionally, age and sex distribution between categories was compared.

Results: The odds ratios for head and neck cancer sites associated with smoking duration differed between less developed and more developed countries. Smoking greater than 20 years conferred a higher risk for oral cavity and laryngeal cancer in more developed countries, whereas the risk was greater for oropharynx and hypopharynx cancer in less developed countries. Alcohol consumed for more than 20 years conferred a higher risk for oropharynx, hypopharynx, and larynx cancer in less developed countries. The proportion of cases that were young (<45 years) or female differed by country type for some HNC subsites.

Conclusion: These findings suggest the degree of industrialization and economic development affects the relationship between smoking and alcohol with head and neck cancer.

Keywords: INHANCE; alcohol use; head and neck cancer; smoking; socioeconomic status.

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