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Review
. 2022 Apr:75:102072.
doi: 10.1016/j.ceb.2022.02.006. Epub 2022 Mar 16.

Roads and hubs of unconventional protein secretion

Aurore Filaquier  1 , Philippe Marin  1 , Marie-Laure Parmentier  1 , Julien Villeneuve  2
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Free article
Review

Roads and hubs of unconventional protein secretion

Aurore Filaquier et al. Curr Opin Cell Biol. 2022 Apr.
Free article

Abstract

In eukaryotes, there is now compelling evidence that in addition to the conventional endoplasmic reticulum-Golgi secretory pathway, there are additional routes for the export of cytoplasmic proteins with a critical role in numerous physio-pathological conditions. These alternative secretory pathways or unconventional protein secretion (UPS) start now to be molecularly dissected, and while UPS landscape appears to be governed by a striking diversity and heterogeneity of mechanisms, common principles are emerging. We review here the role of key molecular determinants as well as the role of central hubs for UPS, highlighting the plasticity and dynamic properties of membrane-bound compartments. We also describe recent findings that position UPS as an integral component of adaptive responses to cope with particular cellular needs and stresses.

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Conflict of interest statement

Conflict of interest statement Nothing declared.

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