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Comment
. 2022 Mar 22;119(12):e2201396119.
doi: 10.1073/pnas.2201396119. Epub 2022 Mar 15.

Dietary modification of myeloid-derived suppressor cells (MDSC) activity in sepsis

Juan B Ochoa Gautier  1   2
Affiliations
Comment

Dietary modification of myeloid-derived suppressor cells (MDSC) activity in sepsis

Juan B Ochoa Gautier. Proc Natl Acad Sci U S A. .
No abstract available

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Conflict of interest statement

Competing interest statement: J.B.O.G. was the Chief Medical Officer for North America for Nestle Health Science until July 1, 2018 and does not have any current legal, contractual, or economic ties with this company or any interest in any other company. He was the Medical Director for the Surgical Intensive Care Unit at Ochsner Medical Center until November 2019. Ochsner Health and Louisiana State University jointly submitted a patent on arginine deficiency, arginase, and MDSC in COVID-19 but J.B.O.G. does not know the status of this patent.

Figures

Fig. 1.
Fig. 1.
ADS is characterized by a decrease in arginine availability resulting in a cascade of impaired biochemical processes and altered organ physiology, ultimately leading to clinical manifestations of illness. ADS is observed in different illnesses such as cancer, after physical injury (trauma/surgery), hemolytic illnesses, and possibly in certain infections and potentially in sepsis.
See this image and copyright information in PMC

Comment on

  • Beneficial effects of citrulline enteral administration on sepsis-induced T cell mitochondrial dysfunction.
    Reizine F, Grégoire M, Lesouhaitier M, Coirier V, Gauthier J, Delaloy C, Dessauge E, Creusat F, Uhel F, Gacouin A, Dessauge F, Le Naoures C, Moreau C, Bendavid C, Daniel Y, Petitjean K, Bordeau V, Lamaison C, Piau C, Cattoir V, Roussel M, Fromenty B, Michelet C, Le Tulzo Y, Zmijewski J, Thibault R, Cogné M, Tarte K, Tadié JM. Reizine F, et al. Proc Natl Acad Sci U S A. 2022 Feb 22;119(8):e2115139119. doi: 10.1073/pnas.2115139119. Proc Natl Acad Sci U S A. 2022. PMID: 35173051 Free PMC article.

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