Maternal prenatal psychological distress and vitamin intake with children's neurocognitive development

doi:10.1038/s41390-022-02003-0

. 2022 Nov;92(5):1450-1457.

doi: 10.1038/s41390-022-02003-0. Epub 2022 Mar 14.

Maternal prenatal psychological distress and vitamin intake with children's neurocognitive development

Derrick Ssewanyana^{1

2}, Julia A Knight^{2

3}, Stephen G Matthews^{1

4

5

6

7}, Jody Wong², Nadya Adel Khani², Jennifer Lye², Kellie E Murphy^{6

7}, Kim Foshay⁷, Justin Okeke⁷, Stephen J Lye^{1

4

5

6

7}, Rayjean J Hung^{8

9}

Affiliations

¹ Alliance for Human Development, Lunenfeld-Tanenbaum Research Institute, Sinai Health, Toronto, ON, Canada.
² Prosserman Centre for Population Health Research, Lunenfeld-Tanenbaum Research Institute, Sinai Health, Toronto, ON, Canada.
³ Division of Epidemiology, Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada.
⁴ Department of Physiology, University of Toronto, Toronto, ON, Canada.
⁵ Department of Medicine, University of Toronto, Toronto, ON, Canada.
⁶ Department of Obstetrics and Gynaecology, University of Toronto, Toronto, ON, Canada.
⁷ Department of Obstetrics and Gynaecology, Sinai Health System, Toronto, ON, Canada.
⁸ Prosserman Centre for Population Health Research, Lunenfeld-Tanenbaum Research Institute, Sinai Health, Toronto, ON, Canada. rayjean.hung@lunenfeld.ca.
⁹ Division of Epidemiology, Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada. rayjean.hung@lunenfeld.ca.

PMID: 35288638
DOI: 10.1038/s41390-022-02003-0

Maternal prenatal psychological distress and vitamin intake with children's neurocognitive development

Derrick Ssewanyana et al. Pediatr Res. 2022 Nov.

. 2022 Nov;92(5):1450-1457.

doi: 10.1038/s41390-022-02003-0. Epub 2022 Mar 14.

Authors

Affiliations

¹ Alliance for Human Development, Lunenfeld-Tanenbaum Research Institute, Sinai Health, Toronto, ON, Canada.
² Prosserman Centre for Population Health Research, Lunenfeld-Tanenbaum Research Institute, Sinai Health, Toronto, ON, Canada.
³ Division of Epidemiology, Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada.
⁴ Department of Physiology, University of Toronto, Toronto, ON, Canada.
⁵ Department of Medicine, University of Toronto, Toronto, ON, Canada.
⁶ Department of Obstetrics and Gynaecology, University of Toronto, Toronto, ON, Canada.
⁷ Department of Obstetrics and Gynaecology, Sinai Health System, Toronto, ON, Canada.
⁸ Prosserman Centre for Population Health Research, Lunenfeld-Tanenbaum Research Institute, Sinai Health, Toronto, ON, Canada. rayjean.hung@lunenfeld.ca.
⁹ Division of Epidemiology, Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada. rayjean.hung@lunenfeld.ca.

PMID: 35288638
DOI: 10.1038/s41390-022-02003-0

Erratum in

Correction: Maternal prenatal psychological distress and vitamin intake with children's neurocognitive development.
Ssewanyana D, Knight JA, Matthews SG, Wong J, Khani NA, Lye J, Murphy KE, Foshay K, Okeke J, Lye SJ, Hung RJ. Ssewanyana D, et al. Pediatr Res. 2022 Nov;92(5):1487. doi: 10.1038/s41390-022-02057-0. Pediatr Res. 2022. PMID: 35411070 No abstract available.

Abstract

Background: Maternal prenatal psychological distress (PPD) is increasingly linked to sub-optimal child neurodevelopment. Daily intake of prenatal vitamin during pre-conception and early pregnancy may ameliorate the effects of PPD on cognition in the offspring.

Methods: PPD was assessed in early (12-16 weeks) and late (28-32 weeks) gestation in the Ontario Birth Study. Prenatal vitamin supplement intake information was collected in early gestation. Child cognition at 4 years was assessed using the NIH Toolbox. Poisson regression was used to investigate associations between PPD and/or prenatal vitamin intake and child cognition.

Results: Four hundred and eighteen mother-child dyads were assessed. Moderate-severe PPD experienced during early gestation was associated with reduced cognition (adjusted incidence rate ratio (IRR_adj) = 3.71, 95% confidence interval (CI): 1.57-8.77, P = 0.003). Daily intake of prenatal vitamins was not associated with cognition (IRR_adj = 1.34, 95% CI: 0.73-2.46, P = 0.34). Upon stratification, the experience of mild-severe PPD with daily intake of prenatal vitamins was associated with higher incident rates of suboptimal cognition compared to children of women with daily prenatal vitamin intake without any episode of PPD (IRR_adj = 2.88, 95% CI: 1.1-7.4).

Conclusions: Moderate-severe PPD in early pregnancy is associated with poor cognition in children and daily intake of prenatal vitamin did not ameliorate this association.

Impact: Our findings expand on existing literature by highlighting that exposure to prenatal psychological distress (PPD), in moderate-to-severe form, in the early stages of pregnancy, can have detrimental effects on the offspring's cognitive development at 4 years. Overall, prenatal vitamin intake did not ameliorate the effects of PPD. Early screening and treatment of prenatal maternal mental illness is crucial.

PubMed Disclaimer

References

1. Fawcett, E. J., Fairbrother, N., Cox, M. L., White, I. R. & Fawcett, J. M. The prevalence of anxiety disorders during pregnancy and the postpartum period: a multivariate Bayesian meta-analysis. J. Clin. Psychiatry 80, 18r12527 (2019).
1. Woody, C., Ferrari, A., Siskind, D., Whiteford, H. & Harris, M. A systematic review and meta-regression of the prevalence and incidence of perinatal depression. J. Affect. Disord. 219, 86–92 (2017). - PubMed - DOI
1. Underwood, L., Waldie, K., D’Souza, S., Peterson, E. R. & Morton, S. A. review of longitudinal studies on antenatal and postnatal depression. Arch. Womens Ment. Health 19, 711–720 (2016). - PubMed - DOI
1. Dennis, C.-L., Falah-Hassani, K. & Shiri, R. Prevalence of antenatal and postnatal anxiety: systematic review and meta-analysis. Br. J. Psychiatry 210, 315–323 (2017). - PubMed - DOI
1. Middleton, H. & Shaw, I. Distinguishing mental illness in primary care: We need to separate proper syndromes from generalised distress. BMJ 320, 1420–1421 (2000). - PubMed - PMC - DOI

Publication types

Actions

MeSH terms

Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions

Substances

Actions

LinkOut - more resources

Full Text Sources
- Nature Publishing Group

[1] Fawcett, E. J., Fairbrother, N., Cox, M. L., White, I. R. & Fawcett, J. M. The prevalence of anxiety disorders during pregnancy and the postpartum period: a multivariate Bayesian meta-analysis. J. Clin. Psychiatry 80, 18r12527 (2019).

[2] Fawcett, E. J., Fairbrother, N., Cox, M. L., White, I. R. & Fawcett, J. M. The prevalence of anxiety disorders during pregnancy and the postpartum period: a multivariate Bayesian meta-analysis. J. Clin. Psychiatry 80, 18r12527 (2019).

[3] Woody, C., Ferrari, A., Siskind, D., Whiteford, H. & Harris, M. A systematic review and meta-regression of the prevalence and incidence of perinatal depression. J. Affect. Disord. 219, 86–92 (2017). - PubMed - DOI

[4] Woody, C., Ferrari, A., Siskind, D., Whiteford, H. & Harris, M. A systematic review and meta-regression of the prevalence and incidence of perinatal depression. J. Affect. Disord. 219, 86–92 (2017). - PubMed - DOI

[5] Underwood, L., Waldie, K., D’Souza, S., Peterson, E. R. & Morton, S. A. review of longitudinal studies on antenatal and postnatal depression. Arch. Womens Ment. Health 19, 711–720 (2016). - PubMed - DOI

[6] Underwood, L., Waldie, K., D’Souza, S., Peterson, E. R. & Morton, S. A. review of longitudinal studies on antenatal and postnatal depression. Arch. Womens Ment. Health 19, 711–720 (2016). - PubMed - DOI

[7] Dennis, C.-L., Falah-Hassani, K. & Shiri, R. Prevalence of antenatal and postnatal anxiety: systematic review and meta-analysis. Br. J. Psychiatry 210, 315–323 (2017). - PubMed - DOI

[8] Dennis, C.-L., Falah-Hassani, K. & Shiri, R. Prevalence of antenatal and postnatal anxiety: systematic review and meta-analysis. Br. J. Psychiatry 210, 315–323 (2017). - PubMed - DOI

[9] Middleton, H. & Shaw, I. Distinguishing mental illness in primary care: We need to separate proper syndromes from generalised distress. BMJ 320, 1420–1421 (2000). - PubMed - PMC - DOI

[10] Middleton, H. & Shaw, I. Distinguishing mental illness in primary care: We need to separate proper syndromes from generalised distress. BMJ 320, 1420–1421 (2000). - PubMed - PMC - DOI

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

Maternal prenatal psychological distress and vitamin intake with children's neurocognitive development

Affiliations

Maternal prenatal psychological distress and vitamin intake with children's neurocognitive development

Authors

Affiliations

Erratum in

Abstract

Similar articles

References

Publication types

MeSH terms

Substances

LinkOut - more resources

Full Text Sources

Erratum in

Abstract

Similar articles

References

Publication types

MeSH terms

Substances

Related information

LinkOut - more resources

Full Text Sources