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Review
. 2022 Feb 22;50(295):48-50.

[Sotrovimab in controlling SARS-CoV-2 infection]

[Article in Polish]
Tadeusz Płusa  1
Affiliations
  • PMID: 35278299
Review

[Sotrovimab in controlling SARS-CoV-2 infection]

[Article in Polish]
Tadeusz Płusa. Pol Merkur Lekarski. .

Abstract

The new monoclonal antibodies - VIR -7831 (sotrovimab) and VIR- 7832 - show an action directly targeting the SARS-CoV-2 spike glycoprotein. Moreover, they strongly neutralize in vitro the wild-type Corona virus variants and the omicron variant. Sotrovimab is a monoclonal antibody capable of neutralizing SARS-CoV-2 as well as other sarbecoviruses (SARS-CoV-1 and SARS-CoV). The administration of 500 mg sotrovimab as a 1-hour intravenous infusion in 291 patients with COVID-19 with mild to moderate severity of symptoms prevented disease progression and the need for hospitalization.

Keywords: SARS-CoV-2; efficacy; sotrovimab.

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