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. 2022 Mar 11;12(1):4296.
doi: 10.1038/s41598-022-08325-7.

Long-term incidence of posterior capsular opacification in patients with non-infectious uveitis

Yuki Kitaguchi-Iwakiri  1 , Koju Kamoi  2 , Hiroshi Takase  1 , Yusuke Okubo  3   4 , Kyoko Ohno-Matsui  1
Affiliations

Long-term incidence of posterior capsular opacification in patients with non-infectious uveitis

Yuki Kitaguchi-Iwakiri et al. Sci Rep. .

Abstract

Little is known about the long-term incidence of posterior capsule opacification (PCO) after cataract surgery in patients with uveitis. This retrospective study included 211 eyes of 146 patients with non-infectious uveitis who underwent cataract surgery and implantation of an Acrysof SN60WF (Surface: plasma-treated, Optic and Haptic: hydrophobic acrylic), iSert XY-1 (Surface: UV-ozone-treated, Optic and Haptic: hydrophobic acrylic), or iSert 251/255 (Surface: UV-ozone-treated, Optics: hydrophobic acrylic, Haptic: polymethyl methacrylate). The cumulative incidences of PCO and subsequent yttrium-aluminum-garnet (Nd:YAG) capsulotomy over the 5-year follow-up were analyzed, and patients who were implanted with different intraocular lenses (IOLs) were compared. Mixed-effects Cox proportional hazard models showed that, compared with the Acrysof group, the iSert XY-1 group had higher risks of PCO (adjusted HR, 7.26; 95% CI, 1.82-28.8) and Nd:YAG capsulotomy (adjusted HR, 6.50; 95% CI, 1.55-27.2). Similar results were obtained when the Acrysof group was compared with the iSert 251/255 group for PCO (adjusted HR, 8.22; 95% CI, 2.35-28.7) and Nd:YAG capsulotomy (adjusted HR, 8.26; 1.90-36.0). These data suggest that a plasma-treated surface, hydrophobic acrylic optic and hydrophobic acrylic haptic, of the IOL could enhance biocompatibility even under inflammatory conditions, thus suppressing PCO development.

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Conflict of interest statement

The authors declare no competing interests.

Figures

Figure 1
Figure 1
Cumulative survival curves of posterior capsule opacification (PCO). (A) Acrysof group. (B) iSert XY-1 group. (C) iSert 251/255 group. A difference is observed at the initial time point, with the Acrysof group exhibiting a significantly lower incidence of PCO than the iSert XY-1 and iSert 251/255 groups over the 5 years (log-rank test, p < 0.001).
Figure 2
Figure 2
Cumulative survival curves of Nd:YAG capsulotomy. (A) Acrysof group. (B) iSert XY-1 group. (C) iSert 251/255 group. A difference is observed at the initial time point. The incidence of Nd:YAG capsulotomy over the 5-year follow-up is significantly lower in the Acrysof group than in the iSert group (log-rank test, p < 0.001).
Figure 3
Figure 3
Changes in Visual acuity (VA). (A) Acrysof group. (B) iSert XY-1 group. (C) iSert 251/255 group. A significant improvement in VA (logMAR) is observed after cataract surgery in all groups. However, there is no significant difference in VA among groups at each time point, but slightly better VA is observed in the Acrysof group at 5 years.
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