Molecular Mechanisms of Exercise and Healthspan

doi:10.3390/cells11050872

Review

. 2022 Mar 3;11(5):872.

doi: 10.3390/cells11050872.

Molecular Mechanisms of Exercise and Healthspan

Yuntian Guan^{1

2}, Zhen Yan^{1

2

3

4}

Affiliations

¹ Department of Pharmacology, School of Medicine, University of Virginia, Charlottesville, VA 22903, USA.
² Center for Skeletal Muscle Research at the Robert M. Berne Cardiovascular Research Center, School of Medicine, University of Virginia, Charlottesville, VA 22903, USA.
³ Department of Medicine, School of Medicine, University of Virginia, Charlottesville, VA 22903, USA.
⁴ Department of Molecular Physiology and Biological Biophysics, School of Medicine, University of Virginia, Charlottesville, VA 22903, USA.

PMID: 35269492
PMCID: PMC8909156
DOI: 10.3390/cells11050872

Review

Molecular Mechanisms of Exercise and Healthspan

Yuntian Guan et al. Cells. 2022.

. 2022 Mar 3;11(5):872.

doi: 10.3390/cells11050872.

Authors

Yuntian Guan^{1

2}, Zhen Yan^{1

2

3

4}

Affiliations

¹ Department of Pharmacology, School of Medicine, University of Virginia, Charlottesville, VA 22903, USA.
² Center for Skeletal Muscle Research at the Robert M. Berne Cardiovascular Research Center, School of Medicine, University of Virginia, Charlottesville, VA 22903, USA.
³ Department of Medicine, School of Medicine, University of Virginia, Charlottesville, VA 22903, USA.
⁴ Department of Molecular Physiology and Biological Biophysics, School of Medicine, University of Virginia, Charlottesville, VA 22903, USA.

PMID: 35269492
PMCID: PMC8909156
DOI: 10.3390/cells11050872

Abstract

Healthspan is the period of our life without major debilitating diseases. In the modern world where unhealthy lifestyle choices and chronic diseases taper the healthspan, which lead to an enormous economic burden, finding ways to promote healthspan becomes a pressing goal of the scientific community. Exercise, one of humanity's most ancient and effective lifestyle interventions, appears to be at the center of the solution since it can both treat and prevent the occurrence of many chronic diseases. Here, we will review the current evidence and opinions about regular exercise promoting healthspan through enhancing the functionality of our organ systems and preventing diseases.

Keywords: adaptations; chronic diseases; exercise; healthspan.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

**Figure 1**
Illustration of exercise benefits in prolonging healthspan.

See this image and copyright information in PMC

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References

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[1] Katz B. 2000-Year-Old Texts Reveal the First Emperor of China’s Quest for Eternal Life. [(accessed on 24 December 2021)]. Available online: https://www.smithsonianmag.com/smart-news/2000-year-old-texts-reveal-fir...

[2] Katz B. 2000-Year-Old Texts Reveal the First Emperor of China’s Quest for Eternal Life. [(accessed on 24 December 2021)]. Available online: https://www.smithsonianmag.com/smart-news/2000-year-old-texts-reveal-fir...

[3] Medina L., Sabo S., Vespa J. Living Longer: Historical and Projected Life Expectancy in the United States, 1960 to 2060. U.S. Department of Commerce, U.S. Census Bureau; Suitland, MD, USA: 2020.

[4] Medina L., Sabo S., Vespa J. Living Longer: Historical and Projected Life Expectancy in the United States, 1960 to 2060. U.S. Department of Commerce, U.S. Census Bureau; Suitland, MD, USA: 2020.

[5] United Nations Department of Economic and Social Affairs Population Division . World Population Ageing 2020 Highlights: Living Arrangements of Older Persons (ST/ESA/SER.A/451) United Nations Department of Economic and Social Affairs; New York, NY, USA: 2020.

[6] United Nations Department of Economic and Social Affairs Population Division . World Population Ageing 2020 Highlights: Living Arrangements of Older Persons (ST/ESA/SER.A/451) United Nations Department of Economic and Social Affairs; New York, NY, USA: 2020.

[7] Zhang Z.D., Milman S., Lin J.R., Wierbowski S., Yu H., Barzilai N., Gorbunova V., Ladiges W.C., Niedernhofer L.J., Suh Y., et al. Genetics of extreme human longevity to guide drug discovery for healthy ageing. Nat. Metab. 2020;2:663–672. doi: 10.1038/s42255-020-0247-0. - DOI - PMC - PubMed

[8] Zhang Z.D., Milman S., Lin J.R., Wierbowski S., Yu H., Barzilai N., Gorbunova V., Ladiges W.C., Niedernhofer L.J., Suh Y., et al. Genetics of extreme human longevity to guide drug discovery for healthy ageing. Nat. Metab. 2020;2:663–672. doi: 10.1038/s42255-020-0247-0. - DOI - PMC - PubMed

[9] Pifferi F., Aujard F. Caloric restriction, longevity and aging: Recent contributions from human and non-human primate studies. Prog. Neuropsychopharmacol. Biol. Psychiatry. 2019;95:109702. doi: 10.1016/j.pnpbp.2019.109702. - DOI - PubMed

[10] Pifferi F., Aujard F. Caloric restriction, longevity and aging: Recent contributions from human and non-human primate studies. Prog. Neuropsychopharmacol. Biol. Psychiatry. 2019;95:109702. doi: 10.1016/j.pnpbp.2019.109702. - DOI - PubMed

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Molecular Mechanisms of Exercise and Healthspan

Affiliations

Molecular Mechanisms of Exercise and Healthspan

Authors

Affiliations

Abstract

Conflict of interest statement

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