Are we there yet? Driving the road to evolutionary graph-pangenomics
- PMID: 35217472
- DOI: 10.1016/j.pbi.2022.102195
Are we there yet? Driving the road to evolutionary graph-pangenomics
Abstract
With increase in the number of sequenced genomes, it is now recognized that graph-based pangenomes can provide a comprehensive platform to study diversity in a population or species, from point mutations to large chromosomal rearrangements. By incorporating concepts from graph theory, a graph-pangenome can be studied directly to identify genomic regions and genes that underlie important evolutionary processes and traits. Here, I discuss how basic concepts in graph theory can be implemented to address questions in evolutionary genomics and guide future breeding efforts. Despite its compelling versatility, a graph-pangenome assembly is still challenging especially in species with large complex genomes. As technology is rapidly improving, the graph-pangenome is expected to become a central platform in genomics studies and applications. Thus, development of tools and methods that exploit the graph structure are urged to pave the route to evolutionary graph-pangenomics.
Keywords: Diversity; Evolution; Genomics; Graph-genome; Pan-genome; Population genomics.
Copyright © 2022 Elsevier Ltd. All rights reserved.
Conflict of interest statement
Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this article.
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