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Review
. 2022 Feb 14:2022:3851225.
doi: 10.1155/2022/3851225. eCollection 2022.

Preeclampsia, Natural History, Genes, and miRNAs Associated with the Syndrome

Laura Parada-Niño  1 , Luisa Fernanda Castillo-León  1 , Adrien Morel  1
Affiliations
Review

Preeclampsia, Natural History, Genes, and miRNAs Associated with the Syndrome

Laura Parada-Niño et al. J Pregnancy. .

Abstract

Preeclampsia (PE) is a hypertensive disease that affects pregnant women after 20 weeks of gestation. This disease is associated with an important risk of maternal and fetal mortality. PE is described as a placental pathology because, after delivery, most women recover normal arterial pressure. Poor invasion of the spiral arteries is a phenomenon well described in PE; this leads to a hypoxic uterine bed and imbalance of antiangiogenic and proangiogenic factors in the uteroplacental region, which in turn triggers the disease phenotype. The causes of the pathology are unclear; nevertheless, numerous approaches, including next-generation sequencing, association, and case control and miRNA studies, have shed light on the genetic/molecular basis of PE. These studies help us better understand the disease to advance new treatment strategies.

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Conflict of interest statement

There are no conflicts of interest.

Figures

Figure 1
Figure 1
Key points of Preeclampsia (PE). A) Factors involved in PE. B) Deficient invasion of trophoblast in spiral arteries.
See this image and copyright information in PMC

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References

    1. Agrawal S., Shinar S., Cerdeira A. S., Redman C., Vatish M. Predictive performance of PlGF (placental growth factor) for screening preeclampsia in asymptomatic women: a systematic review and meta-analysis. Hypertension . 2019;74(5):1124–1135. - PubMed
    1. Mol B. W. J., Roberts C. T., Thangaratinam S., Magee L. A., Hofmeyr G. J. Pre-eclampsia. The Lancet . 2016;387(10022):999–1011. doi: 10.1016/S0140-6736(15)00070-7. - DOI - PubMed
    1. Brown M. A., Magee L. A., Kenny L. C., et al. The hypertensive disorders of pregnancy: ISSHP classification, diagnosis & management recommendations for international practice. Pregnancy Hypertension . 2018;13:291–310. doi: 10.1016/j.preghy.2018.05.004. - DOI - PubMed
    1. Chaiworapongsa T., Chaemsaithong P., Yeo L., Romero R. Pre-eclampsia part 1: current understanding of its pathophysiology. Nature Reviews. Nephrology . 2014;10:466–480. - PMC - PubMed
    1. American College of Obstetricians and Gynecologists. Hypertension in pregnancy . American College of Obstetricians and Gynecologists; 2013.