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Review
. 2022 Jan 27:13:817942.
doi: 10.3389/fimmu.2022.817942. eCollection 2022.

Roles of the Exosomes Derived From Myeloid-Derived Suppressor Cells in Tumor Immunity and Cancer Progression

Zhuang Chen  1 , Rui Yuan  1 , Shengyun Hu  1 , Weitang Yuan  1 , Zhenqiang Sun  1
Affiliations
Review

Roles of the Exosomes Derived From Myeloid-Derived Suppressor Cells in Tumor Immunity and Cancer Progression

Zhuang Chen et al. Front Immunol. .

Abstract

Tumor immunity is involved in malignant tumor progression. Myeloid-derived suppressor cells (MDSCs) play an irreplaceable role in tumor immunity. MDSCs are composed of immature myeloid cells and exhibit obvious immunomodulatory functions. Exosomes released by MDSCs (MDSCs-Exos) have similar effects to parental MDSCs in regulating tumor immunity. In this review, we provided a comprehensive description of the characteristics, functions and mechanisms of exosomes. We analyzed the immunosuppressive, angiogenesis and metastatic effects of MDSCs-Exos in different tumors through multiple perspectives. Immunotherapy targeting MDSCs-Exos has demonstrated great potential in cancers and non-cancerous diseases.

Keywords: cancer; exosome; immune escape; myeloid-derived suppressor cells; tumor immunity.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Immunoregulator effects of MDSCs-Exos in cancers.
Figure 2
Figure 2
(A) In DSS-induced colitis, G-MDSCs-Exos inhibited the proliferation of Th1 cells, promoted the proliferation of Treg cells, and decreased serum IFN-g and TNF-AIN levels in mice. (B) Maternal peripheral blood G-MDSCs-Exos regulated different subtypes of T cell differentiation and function. (C) MDSCs-Exos inhibited AA progression and promoted hair regrowth. (D) G-MDSCs-Exos attenuated CIA in mice by regulating Th1, Th17 and Breg cells.
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References

    1. Fan CM, Wang JP, Tang YY, Zhao J, He SY, Xiong F, et al. . Circman1a2 Could Serve as a Novel Serum Biomarker for Malignant Tumors. Cancer Sci (2019) 110(7):2180–8. doi: 10.1111/cas.14034 - DOI - PMC - PubMed
    1. Gabrilovich DI, Nagaraj S. Myeloid-Derived Suppressor Cells as Regulators of the Immune System. Nat Rev Immunol (2009) 9(3):162–74. doi: 10.1038/nri2506 - DOI - PMC - PubMed
    1. Zhao Y, Shao Q, Zhu H, Xu H, Long W, Yu B, et al. . Resveratrol Ameliorates Lewis Lung Carcinoma-Bearing Mice Development, Decreases Granulocytic Myeloid-Derived Suppressor Cell Accumulation and Impairs Its Suppressive Ability. Cancer Sci (2018) 109(9):2677–86. doi: 10.1111/cas.13720 - DOI - PMC - PubMed
    1. Safarzadeh E, Hashemzadeh S, Duijf PHG, Mansoori B, Khaze V, Mohammadi A, et al. . Circulating Myeloid-Derived Suppressor Cells: An Independent Prognostic Factor in Patients With Breast Cancer. J Cell Physiol (2019) 234(4):3515–25. doi: 10.1002/jcp.26896 - DOI - PubMed
    1. Tan Z, Liu L, Chiu MS, Cheung KW, Yan CW, Yu Z, et al. . Virotherapy-Recruited PMN-MDSC Infiltration of Mesothelioma Blocks Antitumor CTL by IL-10-Mediated Dendritic Cell Suppression. Oncoimmunology (2019) 8(1):e1518672. doi: 10.1080/2162402X.2018.1518672 - DOI - PMC - PubMed

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