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Review
. 2023 Mar;43(2):491-510.
doi: 10.1007/s10571-022-01204-9. Epub 2022 Feb 7.

Stem Cell Therapies for Restorative Treatments of Central Nervous System Ischemia-Reperfusion Injury

Qi-Song Su  1   2 , Dong-Lin Zhuang  1   3 , Moussa Ide Nasser  1 , Xiyalatu Sai  4   5 , Gang Deng  1   6 , Ge Li #  7   8 , Ping Zhu #  9   10   11   12   13   14
Affiliations
Review

Stem Cell Therapies for Restorative Treatments of Central Nervous System Ischemia-Reperfusion Injury

Qi-Song Su et al. Cell Mol Neurobiol. 2023 Mar.

Abstract

Ischemic damage to the central nervous system (CNS) is a catastrophic postoperative complication of aortic occlusion subsequent to cardiovascular surgery that can cause brain impairment and sometimes even paraplegia. Over recent years, numerous studies have investigated techniques for protecting and revascularizing the nervous system during intraoperative ischemia; however, owing to a lack of knowledge of the physiological distinctions between the brain and spinal cord, as well as the limited availability of testing techniques and treatments for ischemia-reperfusion injury, the cause of brain and spinal cord ischemia-reperfusion injury remains poorly understood, and no adequate response steps are currently available in the clinic. Given the limited ability of the CNS to repair itself, it is of great clinical value to make full use of the proliferative and differentiation potential of stem cells to repair nerves in degenerated and necrotic regions by stem cell transplantation or mobilization, thereby introducing a novel concept for the treatment of severe CNS ischemia-reperfusion injury. This review summarizes the most recent advances in stem cell therapy for ischemia-reperfusion injury in the brain and spinal cord, aiming to advance basic research and the clinical use of stem cell therapy as a promising treatment for this condition.

Keywords: Cerebral ischemia–reperfusion injury; Functionally enhanced stem cells; Prototype stem cells; Spinal cord ischemia–reperfusion injury; Stem cell therapy.

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