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. 2021 Nov-Dec;14(6):810-815.
doi: 10.25122/jml-2021-0220.

Morphohistochemical alterations of neurons of the supraoptic nucleus of the rat hypothalamus at different durations of the photoperiod and melatonin administration

Roman Yevgenovych Bulyk  1 , Oleksiy Vasyliovych Smetanyuk  1 , Kateryna Vasylivna Vlasova  1 , Mariana Ivanivna Kryvchanska  1 , Vladyslav Romanovych Yosypenko  1 , Volodymyr Leonidovych Voloshyn  1 , Kateryna Yuriivna Tymchuk  1 , Tetyana Sergiivna Bulyk  2 , Larysa Vasylivna Rynzhuk  2 , Michael Ivanovych Sheremet  3 , Dmytro Volodymyrovych Proniaiev  4
Affiliations

Morphohistochemical alterations of neurons of the supraoptic nucleus of the rat hypothalamus at different durations of the photoperiod and melatonin administration

Roman Yevgenovych Bulyk et al. J Med Life. 2021 Nov-Dec.

Abstract

We studied the morphologic and histochemical organization of neurons of the hypothalamic supraoptic nucleus in rats exposed to different durations of photoperiod and injection of melatonin. Morphometric and histochemical analyses of neurons were performed after staining brain histological sections for RNA. Prolonged illumination leads to more pronounced changes in the parameters of hypothalamic structures at 2 a.m. than at 2 p.m., particularly decreasing the concentration of RNA in the cell nuclei. The use of exogenous melatonin does not normalize the revealed changes in the parameters of the studied structures of the neurons of the supraoptic nucleus of the hypothalamus caused by the prolonged stay of rats under conditions of constant illumination.

Keywords: hypothalamus; melatonin; photoperiod; supraoptic nucleus.

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