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. 2022 Jan 27:2022:5103768.
doi: 10.1155/2022/5103768. eCollection 2022.

Effects of Chinese Medicine on the Survival of AIDS Patients Administered Second-Line ART in Rural Areas of China: A Retrospective Cohort Study Based on Real-World Data

Yantao Jin  1   2 , Miao Zhang  3 , Yanmin Ma  4 , Feng Sang  2 , Pengyu Li  1 , Chunling Yang  3 , Dongli Wang  2 , Huijun Guo  1 , Zhibin Liu  1   3 , Qianlei Xu  2   3
Affiliations

Effects of Chinese Medicine on the Survival of AIDS Patients Administered Second-Line ART in Rural Areas of China: A Retrospective Cohort Study Based on Real-World Data

Yantao Jin et al. Evid Based Complement Alternat Med. .

Abstract

Objectives: Chinese medicine (CM) improves the symptoms of patients with acquired immune deficiency syndrome (AIDS) and prolongs their survival. This real-world study aimed to evaluate the effects of CM on the survival of AIDS patients administered second-line antiretroviral therapy (ART).

Methods: We conducted a retrospective cohort study of the medical records of patients with AIDS who switched to second-line ART between January 2009 and December 2014. Patients were divided into ART and CM + ART groups. Propensity score matching (PSM) was performed to correct for biases between groups. Kaplan-Meier analysis and the log-rank test were used to compare survival rates, and Cox regression models were employed to identify factors significantly associated with survival.

Results: The study population (n = 4180) was comprised of the CM + ART group (n = 855) and the ART group (n = 3325). After 1 : 2 PSM, 855 patients in the CM + ART group and 1699 in the ART group were selected for analysis. Patients in the CM + ART group were followed for 4246.8 person-years, and the mortality rate was 2.12/100 person-years. Patients in the ART group were followed for 8381.2 person-years, and the mortality rate was 2.91/100 person-years. Cox regression model analysis revealed that patients in the CM + ART group survived significantly longer than those in the ART group (hazard ratio: 0.73 and 95% confidence interval: 0.57-0.93). Gender, age, symptoms, CD4 cell counts, and viral loads were independently associated with the survival of AIDS patients treated with second-line ART.

Conclusions: CM significantly improved the survival rate of AIDS patients treated with second-line ART.

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Conflict of interest statement

The authors declare that there are no conflicts of interest regarding the publication of this study.

Figures

Figure 1
Figure 1
The balance between the CM + ART and ART groups after PSM. (a) Histograms of the propensity scores of the two groups before and after matching; (b) standardized difference (SD) of baseline characteristics of the two groups before and after matching.
Figure 2
Figure 2
Kaplan–Meier survival analysis of patients with AIDS treated with second-line ART after PSM.
Figure 3
Figure 3
The Cox proportional hazards model analysis showing the significance of the associations of variables with mortality of patients with AIDS.
See this image and copyright information in PMC

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