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Review
. 2022 Jan 14:2:832976.
doi: 10.3389/froh.2021.832976. eCollection 2021.

A Review of Antimicrobial Activity of Dental Mesenchymal Stromal Cells: Is There Any Potential?

Oleh Andrukhov  1 , Alice Blufstein  1   2 , Christian Behm  1
Affiliations
Review

A Review of Antimicrobial Activity of Dental Mesenchymal Stromal Cells: Is There Any Potential?

Oleh Andrukhov et al. Front Oral Health. .

Abstract

Antimicrobial defense is an essential component of host-microbial homeostasis and contributes substantially to oral health maintenance. Dental mesenchymal stromal cells (MSCs) possess multilineage differentiation potential, immunomodulatory properties and play an important role in various processes like regeneration and disease progression. Recent studies show that dental MSCs might also be involved in antibacterial defense. This occurs by producing antimicrobial peptides or attracting professional phagocytic immune cells and modulating their activity. The production of antimicrobial peptides and immunomodulatory abilities of dental MSCs are enhanced by an inflammatory environment and influenced by vitamin D3. Antimicrobial peptides also have anti-inflammatory effects in dental MSCs and improve their differentiation potential. Augmentation of antibacterial efficiency of dental MSCs could broaden their clinical application in dentistry.

Keywords: Vitamin D3; antimicrobial peptides; dental mesenchymal stromal cells; immunomodulation; oral health.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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References

    1. Kantarci A, Hasturk H. Microbes and host response: a relationship between health and disease. Oral Dis. (2018) 24:1385–7. 10.1111/odi.12731 - DOI - PubMed
    1. Freire M, Nelson KE, Edlund A. The Oral Host-Microbial Interactome: an ecological chronometer of health? Trends Microbiol. (2021) 29:551–61. 10.1016/j.tim.2020.11.004 - DOI - PubMed
    1. Rosier BT, Marsh PD, Mira A. Resilience of the oral microbiota in health: mechanisms that prevent dysbiosis. J Dent Res. (2018) 97:371–80. 10.1177/0022034517742139 - DOI - PubMed
    1. Lamont RJ, Koo H, Hajishengallis G. The oral microbiota: dynamic communities and host interactions. Nat Rev Microbiol. (2018) 16:745–59. 10.1038/s41579-018-0089-x - DOI - PMC - PubMed
    1. Hajishengallis E, Parsaei Y, Klein MI, Koo H. Advances in the microbial etiology and pathogenesis of early childhood caries. Mol Oral Microbiol. (2017) 32:24–34. 10.1111/omi.12152 - DOI - PMC - PubMed

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