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. 2022;86(1):271-281.
doi: 10.3233/JAD-215200.

Predictors of Life Expectancy in Autopsy-Confirmed Alzheimer's Disease

Jeff Schaffert  1 , Christian LoBue  1   2 , Linda S Hynan  1   3 , John Hart  1   4   5 , Heidi Rossetti  1 , Anne R Carlew  1 , Laura Lacritz  1   5 , Charles L White  6 , C Munro Cullum  1   2   5
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Predictors of Life Expectancy in Autopsy-Confirmed Alzheimer's Disease

Jeff Schaffert et al. J Alzheimers Dis. 2022.

Erratum in

Abstract

Background: Life expectancy (LE) following Alzheimer's disease (AD) is highly variable. The literature to date is limited by smaller sample sizes and clinical diagnoses.

Objective: No study to date has evaluated predictors of AD LE in a retrospective large autopsy-confirmed sample, which was the primary objective of this study.

Methods: Participants (≥50 years old) clinically and neuropathologically diagnosed with AD were evaluated using National Alzheimer's Coordinating Center (N = 1,401) data. Analyses focused on 21 demographic, medical, neuropsychiatric, neurological, functional, and global cognitive predictors of LE at AD dementia diagnosis. These 21 predictors were evaluated in univariate analyses. Variables found to be significant were then entered into a forward multiple regression. LE was defined as months between AD diagnosis and death.

Results: Fourteen predictors were significant in univariate analyses and entered into the regression. Seven predictors explained 27% of LE variance in 764 total participants. Mini-Mental State Examination (MMSE) score was the strongest predictor of LE, followed by sex, age, race/ethnicity, neuropsychiatric symptoms, abnormal neurological exam results, and functional impairment ratings. Post-hoc analyses revealed correlations of LE were strongest with MMSE ≤12.

Conclusion: Global cognitive functioning was the strongest predictor of LE following diagnosis, and AD patients with severe impairment had the shortest LE. AD patients who are older, male, white, and have more motor symptoms, functional impairment, and neuropsychiatric symptoms were also more likely have shorter LE. While this model cannot provide individual prognoses, additional studies may focus on these variables to enhance predictions of LE in patients with AD.

Keywords: Alzheimer’s disease; autopsy-confirmed; dementia; life expectancy; mortality.

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References

    1. Alzheimer’s Association (2018) 2018 Alzheimer’s disease facts and figures. Alzheimers Dement 14, 367–429.
    1. Todd S, Barr S, Roberts M, Passmore AP (2013) Survival in dementia and predictors of mortality: A review. Int J Geriatr Psychiatry 28, 1109–1124. - PubMed
    1. Brookmeyer R, Corrada MM, Curriero FC, Kawas C (2002) Survival following a diagnosis of Alzheimer disease. Arch Neurol 59, 1764–1767. - PubMed
    1. Xie J, Brayne C, Matthews FE (2008) Survival times in people with dementia: Analysis from population based cohort study with 14 year follow-up. BMJ 336, 258–262. - PMC - PubMed
    1. Mayeda ER, Glymour MM, Quesenberry CP, Johnson JK, Pérez-Stable EJ, Whitmer RA (2017) Survival after dementia diagnosis in five racial/ethnic groups. Alzheimers Dement 13, 761–769. - PMC - PubMed

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