Ultrapure Wood Nanocellulose-Assessments of Coagulation and Initial Inflammation Potential

doi:10.1021/acsabm.8b00711

. 2019 Mar 18;2(3):1107-1118.

doi: 10.1021/acsabm.8b00711. Epub 2019 Feb 14.

Ultrapure Wood Nanocellulose-Assessments of Coagulation and Initial Inflammation Potential

Henriette R Nordli¹, Brita Pukstad^{1

2}, Gary Chinga-Carrasco³, Anne M Rokstad^{1

4

5}

Affiliations

¹ Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, NO-7491 Trondheim, Norway.
² Department of Dermatology, St. Olavs Hospital, Trondheim University Hospital, NO-7006 Trondheim, Norway.
³ RISE PFI, Høgskoleringen 6b, NO-7491 Trondheim, Norway.
⁴ Centre of Molecular Inflammation Research, NO-7491 Trondheim, Norway.
⁵ Clinic of Surgery, Centre for Obesity, St. Olavs University Hospital, NO-2006 Trondheim, Norway.

PMID: 35021361
DOI: 10.1021/acsabm.8b00711

Ultrapure Wood Nanocellulose-Assessments of Coagulation and Initial Inflammation Potential

Henriette R Nordli et al. ACS Appl Bio Mater. 2019.

. 2019 Mar 18;2(3):1107-1118.

doi: 10.1021/acsabm.8b00711. Epub 2019 Feb 14.

Authors

Henriette R Nordli¹, Brita Pukstad^{1

2}, Gary Chinga-Carrasco³, Anne M Rokstad^{1

4

5}

Affiliations

¹ Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, NO-7491 Trondheim, Norway.
² Department of Dermatology, St. Olavs Hospital, Trondheim University Hospital, NO-7006 Trondheim, Norway.
³ RISE PFI, Høgskoleringen 6b, NO-7491 Trondheim, Norway.
⁴ Centre of Molecular Inflammation Research, NO-7491 Trondheim, Norway.
⁵ Clinic of Surgery, Centre for Obesity, St. Olavs University Hospital, NO-2006 Trondheim, Norway.

PMID: 35021361
DOI: 10.1021/acsabm.8b00711

Abstract

Using a lepirudin-based human whole blood model, we evaluated the initial inflammatory and coagulation responses of dense and porous ultrapure (<50 endotoxin units/grams) cellulose nanofibrils (CNF), of carboxylated grade. The CNF was compared to the wound dressing AquaCel because it is a potential wound-healing material. The porous CNF aerogels induced the strongest coagulation potential measured as prothrombin factor 1.2 (PTF1.2). AquaCel induced the strongest complement response by terminal complement complex (TCC) and surface C3c. All materials activated leukocytes CD11b, while the levels of only 3 of 27 cytokines were significantly changed, limited to (i) an elevation of the monocyte chemoattractant protein-1 (MCP-1/CCL) by the CNF aerogel, (ii) a reduction of eosinophil chemotactic proteins (eotaxin/CCL11) by the CNF aerogel, and (iii) a reduction of platelet-derived growth factor BB (PDGF-BB) by all CNF materials. In conclusion, the CNF materials and AquaCel differently activate coagulation, complement, and cytokines, improving the selection possibilities in various treatment situations of wound healing.

Keywords: coagulation; complement; cytokines; human whole blood model; ultrapure cellulose nanofibrils; wound dressings.

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Ultrapure Wood Nanocellulose-Assessments of Coagulation and Initial Inflammation Potential

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Ultrapure Wood Nanocellulose-Assessments of Coagulation and Initial Inflammation Potential

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