Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2022 Jan 4;20(1):1.
doi: 10.1186/s13053-021-00208-8.

Germline HOXB13 mutation p.G84E do not confer an increased bladder or kidney cancer risk in polish population

Elżbieta Złowocka-Perłowska  1 , Aleksandra Tołoczko-Grabarek  2 , Jan Lubiński  2
Affiliations

Germline HOXB13 mutation p.G84E do not confer an increased bladder or kidney cancer risk in polish population

Elżbieta Złowocka-Perłowska et al. Hered Cancer Clin Pract. .

Abstract

Introduction: The role of HOXB13 in bladder and renal tumorigenesis is unclear. Our goal was to determine the prevalence of HOXB13 p.G84E mutation in bladder and kidney cancer patients from Poland.

Materials and methods: 1418 patients with bladder cancer and 813 cases with kidney cancer and 4497 controls were genotyped for HOXB13 p.G84E.

Results: p.G84E mutation of HOXB13 gene was detected in three of 1418 (0.2%) bladder cancer cases and in six of 4497 controls (odds ratio [OR], 1.6; 95% CI 0.39-6.36; p = 0.8). Among 813 kidney cancer cases HOXB13 mutations was reported in three patients (0,4%) (odds ratio [OR], (OR = 2,8; 95% CI 0.69-11.11; p = 0.3). In cases with mutations in the HOXB13 gene, the family history of cancer was negative.

Conclusion: HOXB13 mutation was not associated with bladder or kidney cancer. Mutation p.G84E in HOXB13 seem not to play a role in bladder and kidney cancer development in Polish patients.

Keywords: HOXB13; P.G84E mutation.

PubMed Disclaimer

Conflict of interest statement

JL is CEO of Read-Gene S.A. The authors EZ-P, AT-G declare that they have no conflict of interest relevant to this article.

Similar articles

See all similar articles

Cited by

References

    1. Didkowska J, Wojciechowska U, Czaderny K, Olasek P, Nowotwory CA złośliwe w Polsce w 2017 roku, Cancer in Poland in 2017, Krajowy Rejestr Nowotworów, Zakład Epidemiologii i Prewencji Nowotworów, Centrum Onkologii - Instytut im. Marii Skłodowskiej-Curie, Narodowy Program Zwalczania Chorób. Warszawa: Nowotworowych, Ministerstwo Zdrowia, 2017 http://onkologia.org.pl/wp-content/uploads/Nowotwory_2017.pdf
    1. Kantor AF, Hartge P, Hoover RN, Fraumeni JF., Jr Familial and environmental interactions in bladder cancer risk. Int J Cancer. 1985;35(6):703–706. doi: 10.1002/ijc.2910350602. - DOI - PubMed
    1. Hasumi H, Yao M. Hereditary kidney cancer syndromes: Genetic disorders driven by alterations in metabolism and epigenome regulation. Cancer Sci. 2018;109(3):581–586. doi: 10.1111/cas.13503. - DOI - PMC - PubMed
    1. Chang CJ, Chen YL, Hsieh CH, Liu YJ, Yu SL, Chen JJW, Wang CC. J HOXA5 and p53 cooperate to suppress lung cancer cell invasion and serve as good prognostic factors in non-small cell lung cancer. Cancer. 2017;8(6):1071–1081. doi: 10.7150/jca.17295. - DOI - PMC - PubMed
    1. Halachmi S, Madeb R, Kravtsov A, Moskovitz B, Halachmi N, Nativ O. Bladder cancer-genetic overview. Med Sci Monit. 2001;7(1):164–168. - PubMed

LinkOut - more resources