Mechanistic diversity in MHC class I antigen recognition
- PMID: 34940832
- PMCID: PMC8786304
- DOI: 10.1042/BCJ20200910
Mechanistic diversity in MHC class I antigen recognition
Abstract
Throughout its evolution, the human immune system has developed a plethora of strategies to diversify the antigenic peptide sequences that can be targeted by the CD8+ T cell response against pathogens and aberrations of self. Here we provide a general overview of the mechanisms that lead to the diversity of antigens presented by MHC class I complexes and their recognition by CD8+ T cells, together with a more detailed analysis of recent progress in two important areas that are highly controversial: the prevalence and immunological relevance of unconventional antigen peptides; and cross-recognition of antigenic peptides by the T cell receptors of CD8+ T cells.
Keywords: MHC class I; T cells; TCR; antigens; spliced peptides.
© 2021 The Author(s).
Conflict of interest statement
The authors declare that there are no competing interests associated with the manuscript.
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References
-
- Janeway, C.A., Travers, P., Walport, M. and Shlomchik, M.J. (2001) T cell-mediated cytotoxicity. In Immunobiology: The Immune System in Health and Disease, Garland Science, New York
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