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. 2021 Dec 18;13(1):145.
doi: 10.1186/s13098-021-00765-x.

Association of Helicobacter pylori infection with the risk of metabolic syndrome and insulin resistance: an updated systematic review and meta-analysis

Mobin Azami  1 , Hamid Reza Baradaran  2   3 , Hojat Dehghanbanadaki  4 , Parisa Kohnepoushi  1 , Lotfolah Saed  5 , Asra Moradkhani  1 , Farhad Moradpour  6 , Yousef Moradi  7   8
Affiliations

Association of Helicobacter pylori infection with the risk of metabolic syndrome and insulin resistance: an updated systematic review and meta-analysis

Mobin Azami et al. Diabetol Metab Syndr. .

Abstract

Background: Conflicting results of recent studies on the association between Helicobacter pylori (H. pylori) infection and the risk of insulin resistance and metabolic syndrome explored the need for updated meta-analysis on this issue. Therefore, this systematic review aimed to estimate the pooled effect of H. pylori infection on the risk of insulin resistance and metabolic syndrome.

Methods: To identify case-control studies and cohort studies evaluating the association of H. pylori infection with insulin resistance and metabolic syndrome, a comprehensive literature search was performed from international databases including Medline (PubMed), Web of Sciences, Scopus, EMBASE, and CINHAL from January 1990 until January 2021. We used odds ratio with its 95% confidence interval to quantify the effect of case-control studies and risk ratio with its 95% CI for the effect of cohort studies.

Results: 22 studies with 206,911 participants were included for meta-analysis. The pooled estimate of odds ratio between H. pylori infection and metabolic syndrome in case-control studies was 1.19 (95% CI 1.05-1.35; I2 = 0%), and in cohort studies, the pooled risk ratio was 1.31 (95% CI 1.13-1.51; I2 = 0%). Besides, case-control studies showed the pooled odds ratio of 1.54 (95% CI 1.19-1.98; I2 = 6.88%) for the association between H. pylori infection and insulin resistance.

Conclusion: In this meta-analysis, the results showed that there was a possibility of metabolic syndrome and insulin resistance in case of H. pylori infection.

Keywords: Helicobacter pylori; Insulin resistance; Meta-analysis; Metabolic syndrome; Systematic review.

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Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Fig. 1
Fig. 1
PRISMA 2020 flow diagram for new systematic reviews which included searches of databases and registers only
Fig. 2
Fig. 2
The odds ratio (OR) between Helicobacter pylori infection and the occurrence of metabolic syndrome, sensitivity analysis and publication bias using a combination of the results of case–control studies (CI: Confidence Interval)
Fig. 3
Fig. 3
The odds ratio (OR) between Helicobacter pylori infection and insulin resistance, sensitivity analysis and publication bias using a combination of the results of case–control studies (CI: Confidence Interval)
Fig. 4
Fig. 4
The risk ratio (RR) between Helicobacter pylori infection and metabolic syndrome and insulin resistance, sensitivity analysis and publication bias using a combination of the results of cohort studies (CI: Confidence Interval)
Fig. 5
Fig. 5
The meta-regression results in the effect of age and BMI (Body Mass Index) on the association between H. pylori and insulin resistance or metabolic syndrome
See this image and copyright information in PMC

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