Fecal microbiota relationships with childhood obesity: A scoping comprehensive review

doi:10.1111/obr.13394

Review

. 2022 Jan:23 Suppl 1:e13394.

doi: 10.1111/obr.13394. Epub 2021 Dec 15.

Fecal microbiota relationships with childhood obesity: A scoping comprehensive review

Begoña de Cuevillas¹, Fermín I Milagro^{1

2

3}, Josep A Tur^{2

4}, Mercedes Gil-Campos^{2

5}, Pilar de Miguel-Etayo^{2

6}, J Alfredo Martínez^{1

2

3

7}, Santiago Navas-Carretero^{1

2

3}

Affiliations

¹ Center for Nutrition Research, Department of Nutrition, Food Sciences and Physiology. School of Pharmacy and Nutrition, University of Navarra, Pamplona, Spain.
² Centro de Investigación Biomédica en Red de la Fisiopatología de la Obesidad y Nutrición (CIBERobn), Instituto de Salud Carlos III, Madrid, Spain.
³ IdiSNA, Health Research Institute of Navarra, Pamplona, Spain.
⁴ Research Group on Community Nutrition and Oxidative Stress, University of Balearic Islands-IUNICS & IDISBA, Palma de Mallorca, Spain.
⁵ Metabolism and Investigation Unit, Reina Sofia University Hospital, Maimónides Institute of Biomedicine Research of Córdoba (IMIBIC), University of Córdoba, Córdoba, Spain.
⁶ Growth, Exercise, Nutrition and Development (GENUD) Research Group, Instituto Agroalimentario de Aragón (IA2), Universidad de Zaragoza. Instituto de Investigación Sanitaria de Aragón (IIS Aragón), Zaragoza, Spain.
⁷ Precision Nutrition Program, Research Institute on Food and Health Sciences IMDEA Food. CSIC-UAM, Madrid, Spain.

PMID: 34913242
DOI: 10.1111/obr.13394

Review

Fecal microbiota relationships with childhood obesity: A scoping comprehensive review

Begoña de Cuevillas et al. Obes Rev. 2022 Jan.

. 2022 Jan:23 Suppl 1:e13394.

doi: 10.1111/obr.13394. Epub 2021 Dec 15.

Authors

Begoña de Cuevillas¹, Fermín I Milagro^{1

2

3}, Josep A Tur^{2

4}, Mercedes Gil-Campos^{2

5}, Pilar de Miguel-Etayo^{2

6}, J Alfredo Martínez^{1

2

3

7}, Santiago Navas-Carretero^{1

2

3}

Affiliations

¹ Center for Nutrition Research, Department of Nutrition, Food Sciences and Physiology. School of Pharmacy and Nutrition, University of Navarra, Pamplona, Spain.
² Centro de Investigación Biomédica en Red de la Fisiopatología de la Obesidad y Nutrición (CIBERobn), Instituto de Salud Carlos III, Madrid, Spain.
³ IdiSNA, Health Research Institute of Navarra, Pamplona, Spain.
⁴ Research Group on Community Nutrition and Oxidative Stress, University of Balearic Islands-IUNICS & IDISBA, Palma de Mallorca, Spain.
⁵ Metabolism and Investigation Unit, Reina Sofia University Hospital, Maimónides Institute of Biomedicine Research of Córdoba (IMIBIC), University of Córdoba, Córdoba, Spain.
⁶ Growth, Exercise, Nutrition and Development (GENUD) Research Group, Instituto Agroalimentario de Aragón (IA2), Universidad de Zaragoza. Instituto de Investigación Sanitaria de Aragón (IIS Aragón), Zaragoza, Spain.
⁷ Precision Nutrition Program, Research Institute on Food and Health Sciences IMDEA Food. CSIC-UAM, Madrid, Spain.

PMID: 34913242
DOI: 10.1111/obr.13394

Abstract

Childhood obesity is a costly burden in most regions with relevant and adverse long-term health consequences in adult life. Several studies have associated excessive body weight with a specific profile of gut microbiota. Different factors related to fecal microorganism abundance seem to contribute to childhood obesity, such as gestational weight gain, perinatal diet, antibiotic administration to the mother and/or child, birth delivery, and feeding patterns, among others. This review reports and discusses diverse factors that affect the infant intestinal microbiota with putative or possible implications on the increase of the obesity childhood rates as well as microbiota shifts associated with excessive body weight in children.

Keywords: STOP project; childhood obesity; dysbiosis; microbiota.

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References

REFERENCES

1. World Health Organization. Obesity and overweight. World Health Organization. https://www.who.int/news-room/fact-sheets/detail/obesity-and-overweight. Published 2020 Accessed April 20, 2020
1. Reilly JJ, Kelly J. Long-term impact of overweight and obesity in childhood and adolescence on morbidity and premature mortality in adulthood: Systematic review. Int J Obes (Lond). 2011;35(7):891-898. https://doi.org/10.1038/ijo.2010.222
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1. Cameron A, Roubos I, Ewen M, Mantel-Teeuwisse AK, Leufkens HGM, Laing RO. Differences in the availability of medicines for chronic and acute conditions in the public and private sectors of developing countries. Bull World Health Organ. 2011;89(6):412-421. https://doi.org/10.2471/blt.10.084327
1. Ek A, Delisle Nyström C, Chirita-Emandi A, et al. A randomized controlled trial for overweight and obesity in preschoolers: the More and Less Europe study-an intervention within the STOP project. BMC Public Health. 2019;19:945. https://doi.org/10.1186/s12889-019-7161-y

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[1] World Health Organization. Obesity and overweight. World Health Organization. https://www.who.int/news-room/fact-sheets/detail/obesity-and-overweight. Published 2020 Accessed April 20, 2020

[2] World Health Organization. Obesity and overweight. World Health Organization. https://www.who.int/news-room/fact-sheets/detail/obesity-and-overweight. Published 2020 Accessed April 20, 2020

[3] Reilly JJ, Kelly J. Long-term impact of overweight and obesity in childhood and adolescence on morbidity and premature mortality in adulthood: Systematic review. Int J Obes (Lond). 2011;35(7):891-898. https://doi.org/10.1038/ijo.2010.222

[4] Reilly JJ, Kelly J. Long-term impact of overweight and obesity in childhood and adolescence on morbidity and premature mortality in adulthood: Systematic review. Int J Obes (Lond). 2011;35(7):891-898. https://doi.org/10.1038/ijo.2010.222

[5] Kopelman PG. Obesity as a medical problem. Nature. 2000;404(6778):635-643. https://doi.org/10.1038/35007508

[6] Kopelman PG. Obesity as a medical problem. Nature. 2000;404(6778):635-643. https://doi.org/10.1038/35007508

[7] Cameron A, Roubos I, Ewen M, Mantel-Teeuwisse AK, Leufkens HGM, Laing RO. Differences in the availability of medicines for chronic and acute conditions in the public and private sectors of developing countries. Bull World Health Organ. 2011;89(6):412-421. https://doi.org/10.2471/blt.10.084327

[8] Cameron A, Roubos I, Ewen M, Mantel-Teeuwisse AK, Leufkens HGM, Laing RO. Differences in the availability of medicines for chronic and acute conditions in the public and private sectors of developing countries. Bull World Health Organ. 2011;89(6):412-421. https://doi.org/10.2471/blt.10.084327

[9] Ek A, Delisle Nyström C, Chirita-Emandi A, et al. A randomized controlled trial for overweight and obesity in preschoolers: the More and Less Europe study-an intervention within the STOP project. BMC Public Health. 2019;19:945. https://doi.org/10.1186/s12889-019-7161-y

[10] Ek A, Delisle Nyström C, Chirita-Emandi A, et al. A randomized controlled trial for overweight and obesity in preschoolers: the More and Less Europe study-an intervention within the STOP project. BMC Public Health. 2019;19:945. https://doi.org/10.1186/s12889-019-7161-y

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Fecal microbiota relationships with childhood obesity: A scoping comprehensive review

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Fecal microbiota relationships with childhood obesity: A scoping comprehensive review

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