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Review
. 2022 Feb:52:102-111.
doi: 10.1016/j.coviro.2021.11.015. Epub 2021 Dec 11.

Immune responses to human respiratory coronaviruses infection in mouse models

Zhen Zhuang  1 , Donglan Liu  1 , Jing Sun  1 , Fang Li  1 , Jincun Zhao  2
Affiliations
Review

Immune responses to human respiratory coronaviruses infection in mouse models

Zhen Zhuang et al. Curr Opin Virol. 2022 Feb.

Abstract

Human respiratory coronaviruses (HCoVs), including the recently emerged SARS-CoV-2, the causative agent of the coronavirus disease 2019 (COVID-19) pandemic, potentially cause severe lung infections and multiple organ damages, emphasizing the urgent need for antiviral therapeutics and vaccines against HCoVs. Small animal models, especially mice, are ideal tools for deciphering the pathogenesis of HCoV infections as well as virus-induced immune responses, which is critical for antiviral drug development and vaccine design. In this review, we focus on the antiviral innate immune response, antibody response and T cell response in HCoV infected mouse models, and discuss the potential implications for understanding the anti-HCoV immunity and fighting the COVID-19 pandemic.

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Figures

Figure 1
Figure 1
Phylogenetic analyses of Coronaviridae family. All available complete genomes of Coronaviridae family from GenBank were collected and used for the evolutional analysis using MEGA 7.0. Three highly pathogenic (red) and four low pathogenic (blue) human coronaviruses are highlighted in the phylogenetic tree.
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