The calcitonin-like sequence of the beta CGRP gene
- PMID: 3489641
- DOI: 10.1016/0014-5793(86)81338-2
The calcitonin-like sequence of the beta CGRP gene
Abstract
We have identified a region within the beta CGRP gene which has the potential to encode a novel calcitonin-like peptide. The gene is located on the short arm of chromosome 11 (11p 12-14.2) and we suggest that it resulted from a local duplication of the alpha gene. We have been unable to detect the corresponding mRNA in a variety of tissues which express alpha-calcitonin. It is not clear whether this sequence can be expressed in man.
Similar articles
-
Structure and methylation of the human calcitonin/alpha-CGRP gene.Nucleic Acids Res. 1989 Sep 12;17(17):6999-7011. doi: 10.1093/nar/17.17.6999. Nucleic Acids Res. 1989. PMID: 2571128 Free PMC article.
-
A third human CALC (pseudo)gene on chromosome 11.FEBS Lett. 1988 Jun 6;233(1):57-63. doi: 10.1016/0014-5793(88)81355-3. FEBS Lett. 1988. PMID: 2898385
-
Expression of the second calcitonin/calcitonin gene-related peptide gene in Ewing sarcoma cell lines.J Clin Endocrinol Metab. 1987 Apr;64(4):809-17. doi: 10.1210/jcem-64-4-809. J Clin Endocrinol Metab. 1987. PMID: 3493259
-
Molecular mechanisms of cell-specific and regulated expression of the calcitonin/alpha-CGRP and beta-CGRP genes.Ann N Y Acad Sci. 1992 Jun 30;657:36-49. doi: 10.1111/j.1749-6632.1992.tb22755.x. Ann N Y Acad Sci. 1992. PMID: 1637094 Review.
-
Calcitonin and the peptides from the calcitonin gene.Clin Orthop Relat Res. 1987 Apr;(217):45-55. Clin Orthop Relat Res. 1987. PMID: 3549095 Review.
Cited by
-
Intermedin (adrenomedullin-2): a novel counter-regulatory peptide in the cardiovascular and renal systems.Br J Pharmacol. 2008 Mar;153 Suppl 1(Suppl 1):S247-62. doi: 10.1038/sj.bjp.0707494. Epub 2007 Oct 29. Br J Pharmacol. 2008. PMID: 17965749 Free PMC article. Review.
-
Identification of exon sequences and an exon binding protein involved in alternative RNA splicing of calcitonin/CGRP.Nucleic Acids Res. 1992 May 11;20(9):2361-6. doi: 10.1093/nar/20.9.2361. Nucleic Acids Res. 1992. PMID: 1594453 Free PMC article.
-
Structure and methylation of the human calcitonin/alpha-CGRP gene.Nucleic Acids Res. 1989 Sep 12;17(17):6999-7011. doi: 10.1093/nar/17.17.6999. Nucleic Acids Res. 1989. PMID: 2571128 Free PMC article.
-
Comparison between Substance P and Calcitonin Gene-Related Peptide and Their Receptors in Colorectal Adenocarcinoma.J Clin Med. 2024 Sep 22;13(18):5616. doi: 10.3390/jcm13185616. J Clin Med. 2024. PMID: 39337103 Free PMC article.
-
Roles of calcitonin gene-related peptide in the skin, and other physiological and pathophysiological functions.Brain Behav Immun Health. 2021 Oct 5;18:100361. doi: 10.1016/j.bbih.2021.100361. eCollection 2021 Dec. Brain Behav Immun Health. 2021. PMID: 34746878 Free PMC article. Review.
Publication types
MeSH terms
Substances
Associated data
- Actions
LinkOut - more resources
Full Text Sources
Research Materials