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Case Reports
. 2021 Nov 5:19:1-3.
doi: 10.1016/j.jdcr.2021.10.031. eCollection 2022 Jan.

An adult with severe leukocyte adhesion deficiency type 1

Affiliations
Case Reports

An adult with severe leukocyte adhesion deficiency type 1

Marija Geroldinger-Simić et al. JAAD Case Rep. .
No abstract available

Keywords: HSCT, hematopoietic stem cell transplantation; IL, interleukin; ITGB2, integrin β2; LAD-1; LAD-1, leukocyte adhesion deficiency type 1; chronic wounds; leukocyte adhesion deficiency type 1; periodontitis.

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Conflict of interest statement

None disclosed.

Figures

Fig 1
Fig 1
Chronic wound on the right forearm of the 6-year-old patient.
Fig 2
Fig 2
Gingivitis in the 6-year-old patient.
Fig 3
Fig 3
Inflamed ulcer on the left shoulder of the 9-year-old patient.

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References

    1. Crowley C.A., Curnutte J.T., Rosin R.E., et al. An inherited abnormality of neutrophil adhesion. Its genetic transmission and its association with a missing protein. N Engl J Med. 1980;302(21):1163–1168. doi: 10.1056/NEJM198005223022102. - DOI - PubMed
    1. Hogg N., Stewart M.P., Scarth S.L., et al. A novel leukocyte adhesion deficiency caused by expressed but nonfunctional beta2 integrins Mac-1 and LFA-1. J Clin Invest. 1999;103(1):97–106. doi: 10.1172/JCI3312. - DOI - PMC - PubMed
    1. Qasim W., Cavazzana-Calvo M., Davies E.G., et al. Allogeneic hematopoietic stem-cell transplantation for leukocyte adhesion deficiency. Pediatrics. 2009;123(3):836–840. doi: 10.1542/peds.2008-1191. - DOI - PMC - PubMed
    1. Almarza Novoa E., Kasbekar S., Thrasher A.J., et al. Leukocyte adhesion deficiency-I: a comprehensive review of all published cases. J Allergy Clin Immunol Pract. 2018;6(4):1418–1420.e10. doi: 10.1016/j.jaip.2017.12.008. - DOI - PubMed
    1. Bernard Cher T.H., Chan H.S., Klein G.F., et al. A novel 3′ splice-site mutation and a novel gross deletion in leukocyte adhesion deficiency (LAD)-1. Biochem Biophys Res Commun. 2011;404(4):1099–1104. doi: 10.1016/j.bbrc.2010.12.124. - DOI - PubMed

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