Associations of the BDNF Val66Met Polymorphism With Body Composition, Cardiometabolic Risk Factors, and Energy Intake in Youth With Obesity: Findings From the HEARTY Study

doi:10.3389/fnins.2021.715330

. 2021 Nov 12:15:715330.

doi: 10.3389/fnins.2021.715330. eCollection 2021.

Associations of the BDNF Val66Met Polymorphism With Body Composition, Cardiometabolic Risk Factors, and Energy Intake in Youth With Obesity: Findings From the HEARTY Study

Gary S Goldfield^{1

2

3}, Jeremy Walsh⁴, Ronald J Sigal^{3

5

6}, Glen P Kenny^{3

6}, Stasia Hadjiyannakis⁷, Michael De Lisio³, Mathew Ngu³, Denis Prud'homme⁸, Angela S Alberga⁹, Steve Doucette¹⁰, Diana B Goldfield¹¹, Jameason D Cameron¹²

Affiliations

¹ Healthy Active Living and Obesity Research Group, Children's Hospital of Eastern Ontario Research Institute, Ottawa, ON, Canada.
² Department of Pediatrics, University of Ottawa, Ottawa, ON, Canada.
³ School of Human Kinetics, University of Ottawa, Ottawa, ON Canada.
⁴ Department of Kinesiology, McMaster University, Hamilton, ON, Canada.
⁵ Department of Medicine, Cardiac Sciences and Community Health Sciences, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.
⁶ Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, ON, Canada.
⁷ Centre for Healthy Active Living, Children's Hospital of Eastern Ontario, Ottawa, ON, Canada.
⁸ President and Vice Chancellor, University of Moncton, Moncton, NB, Canada.
⁹ Department of Kinesiology, Concordia University, Montreal, QC, Canada.
¹⁰ Department of Community Health and Epidemiology, Dalhousie University, Halifax, NS, Canada.
¹¹ Department of Life Sciences, Queen's University, Kingston, ON, Canada.
¹² Department of Pharmacy, Children's Hospital of Eastern Ontario, Ottawa, ON, Canada.

PMID: 34867148
PMCID: PMC8633533
DOI: 10.3389/fnins.2021.715330

Associations of the BDNF Val66Met Polymorphism With Body Composition, Cardiometabolic Risk Factors, and Energy Intake in Youth With Obesity: Findings From the HEARTY Study

Gary S Goldfield et al. Front Neurosci. 2021.

. 2021 Nov 12:15:715330.

doi: 10.3389/fnins.2021.715330. eCollection 2021.

Authors

Affiliations

¹ Healthy Active Living and Obesity Research Group, Children's Hospital of Eastern Ontario Research Institute, Ottawa, ON, Canada.
² Department of Pediatrics, University of Ottawa, Ottawa, ON, Canada.
³ School of Human Kinetics, University of Ottawa, Ottawa, ON Canada.
⁴ Department of Kinesiology, McMaster University, Hamilton, ON, Canada.
⁵ Department of Medicine, Cardiac Sciences and Community Health Sciences, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.
⁶ Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, ON, Canada.
⁷ Centre for Healthy Active Living, Children's Hospital of Eastern Ontario, Ottawa, ON, Canada.
⁸ President and Vice Chancellor, University of Moncton, Moncton, NB, Canada.
⁹ Department of Kinesiology, Concordia University, Montreal, QC, Canada.
¹⁰ Department of Community Health and Epidemiology, Dalhousie University, Halifax, NS, Canada.
¹¹ Department of Life Sciences, Queen's University, Kingston, ON, Canada.
¹² Department of Pharmacy, Children's Hospital of Eastern Ontario, Ottawa, ON, Canada.

PMID: 34867148
PMCID: PMC8633533
DOI: 10.3389/fnins.2021.715330

Abstract

The brain-derived neurotrophic factor (BDNF) Val66Met polymorphism is functionally related to BDNF, and is associated with obesity and metabolic complications in adults, but limited research exists among adolescents. This study comparatively examined carriers and non-carriers of the BDNF Val66Met polymorphism on body composition, energy intake, and cardiometabolic profile among adolescents with obesity. The sample consisted of 187 adolescents with obesity; 99 were carriers of the homozygous Val (G/G) alleles and 88 were carriers of the Val/Met (G/A) or Met (A/A) alleles. Cardiometabolic profile and DNA were quantified from fasted blood samples. Body composition was assessed by magnetic resonance imaging (MRI). Compared to carriers of the homozygous Val (G/G) allele, carriers of the Val/Met (G/A) or Met/Met (A/A) variants exhibited significantly higher protein (p = 0.01) and fat (p = 0.05) intake, C-Reactive protein (p = 0.05), and a trend toward higher overall energy intake (p = 0.07), fat-free mass (p = 0.07), and lower HDL-C (p = 0.07) Results showed for the first time that among youth with obesity, carriers of the Val66Met BDNF Met-alleles exhibited significantly higher C-reactive protein and energy intake in the form of fat and protein compared to Val-allele carriers, thereby providing support for the possible role of BDNF in appetite, weight, and metabolic regulation during adolescence. Clinical Trial Registration: http://clinicaltrials.gov/, identifier NCT00195858.

Keywords: BDNF; Val66Met; adolescents; cardiometabolic risk; energy intake; gene; obesity.

PubMed Disclaimer

Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Cited by

Reduced Levels of Brain-Derived Neurotrophic Factor Affect Body Weight, Brain Weight and Behavior.
Voigt MW, Schepers J, Haas J, von Bohlen Und Halbach O. Voigt MW, et al. Biology (Basel). 2024 Feb 29;13(3):159. doi: 10.3390/biology13030159. Biology (Basel). 2024. PMID: 38534429 Free PMC article.
A genomics perspective of personalized prevention and management of obesity.
Gkouskou KK, Grammatikopoulou MG, Lazou E, Vasilogiannakopoulou T, Sanoudou D, Eliopoulos AG. Gkouskou KK, et al. Hum Genomics. 2024 Jan 29;18(1):4. doi: 10.1186/s40246-024-00570-3. Hum Genomics. 2024. PMID: 38281958 Free PMC article. Review.
Function of brain-derived neurotrophic factor in the hypothalamus: Implications for depression pathology.
Autry AE. Autry AE. Front Mol Neurosci. 2022 Nov 16;15:1028223. doi: 10.3389/fnmol.2022.1028223. eCollection 2022. Front Mol Neurosci. 2022. PMID: 36466807 Free PMC article. Review.
The Neurotrophin System in the Postnatal Brain-An Introduction.
von Bohlen Und Halbach O, Klausch M. von Bohlen Und Halbach O, et al. Biology (Basel). 2024 Jul 24;13(8):558. doi: 10.3390/biology13080558. Biology (Basel). 2024. PMID: 39194496 Free PMC article. Review.
Water intake and obesity: By amount, timing, and perceived temperature of drinking water.
Khil J, Chen QY, Lee DH, Hong KW, Keum N. Khil J, et al. PLoS One. 2024 Apr 25;19(4):e0301373. doi: 10.1371/journal.pone.0301373. eCollection 2024. PLoS One. 2024. PMID: 38662725 Free PMC article.

See all "Cited by" articles

References

1. Alberga A. S., Goldfield G. S., Kenny G. P., Hadjiyannakis S., Phillips P., Prud’Homme D., et al. (2012). Healthy eating, aerobic and resistance training in youth (HEARTY): study rationale, design and methods. Contemp. Clin. Trials 33 839–847. - PubMed
1. Alberga A. S., Prud’Homme D., Kenny G. P., Goldfield G. S., Hadjiyannakis S., Gougeon R., et al. (2015). Effects of aerobic and resistance training on abdominal fat, apolipoproteins and high-sensitivity C-reactive protein in adolescents with obesity: the HEARTY randomized clinical trial. Int. J. Obes. 39 1494–1500. - PubMed
1. Anastasia A., Deinhardt K., Chao M. V., Will N. E., Irmady K., Lee F. S., et al. (2013). Val66Met polymorphism of BDNF alters prodomain structure to induce neuronal growth cone retraction. Nat. Commun. 4:2490. 10.1038/NCOMMS3490 - DOI - PMC - PubMed
1. Arija V., Ferrer-Barcala M., Aranda N., Canals J. (2010). BDNF Val66Met polymorphism, energy intake and BMI: a follow-up study in schoolchildren at risk of eating disorders. BMC Public Health 10:363. 10.1186/1471-2458-10-363 - DOI - PMC - PubMed
1. Bariohay B., Lebrun B., Moyse E., Jean A. (2005). Brain-derived neurotrophic factor plays a role as an anorexigenic factor in the dorsal vagal complex. Endocrinology 146 5612–5620. 10.1210/en.2005-0419 - DOI - PubMed

Associated data

Actions
- Search in PubMed
- Search in ClinicalTrials.gov

LinkOut - more resources

Full Text Sources
Research Materials
- NCI CPTC Antibody Characterization Program
Miscellaneous
- NCI CPTAC Assay Portal

[1] Alberga A. S., Goldfield G. S., Kenny G. P., Hadjiyannakis S., Phillips P., Prud’Homme D., et al. (2012). Healthy eating, aerobic and resistance training in youth (HEARTY): study rationale, design and methods. Contemp. Clin. Trials 33 839–847. - PubMed

[2] Alberga A. S., Goldfield G. S., Kenny G. P., Hadjiyannakis S., Phillips P., Prud’Homme D., et al. (2012). Healthy eating, aerobic and resistance training in youth (HEARTY): study rationale, design and methods. Contemp. Clin. Trials 33 839–847. - PubMed

[3] Alberga A. S., Prud’Homme D., Kenny G. P., Goldfield G. S., Hadjiyannakis S., Gougeon R., et al. (2015). Effects of aerobic and resistance training on abdominal fat, apolipoproteins and high-sensitivity C-reactive protein in adolescents with obesity: the HEARTY randomized clinical trial. Int. J. Obes. 39 1494–1500. - PubMed

[4] Alberga A. S., Prud’Homme D., Kenny G. P., Goldfield G. S., Hadjiyannakis S., Gougeon R., et al. (2015). Effects of aerobic and resistance training on abdominal fat, apolipoproteins and high-sensitivity C-reactive protein in adolescents with obesity: the HEARTY randomized clinical trial. Int. J. Obes. 39 1494–1500. - PubMed

[5] Anastasia A., Deinhardt K., Chao M. V., Will N. E., Irmady K., Lee F. S., et al. (2013). Val66Met polymorphism of BDNF alters prodomain structure to induce neuronal growth cone retraction. Nat. Commun. 4:2490. 10.1038/NCOMMS3490 - DOI - PMC - PubMed

[6] Anastasia A., Deinhardt K., Chao M. V., Will N. E., Irmady K., Lee F. S., et al. (2013). Val66Met polymorphism of BDNF alters prodomain structure to induce neuronal growth cone retraction. Nat. Commun. 4:2490. 10.1038/NCOMMS3490 - DOI - PMC - PubMed

[7] Arija V., Ferrer-Barcala M., Aranda N., Canals J. (2010). BDNF Val66Met polymorphism, energy intake and BMI: a follow-up study in schoolchildren at risk of eating disorders. BMC Public Health 10:363. 10.1186/1471-2458-10-363 - DOI - PMC - PubMed

[8] Arija V., Ferrer-Barcala M., Aranda N., Canals J. (2010). BDNF Val66Met polymorphism, energy intake and BMI: a follow-up study in schoolchildren at risk of eating disorders. BMC Public Health 10:363. 10.1186/1471-2458-10-363 - DOI - PMC - PubMed

[9] Bariohay B., Lebrun B., Moyse E., Jean A. (2005). Brain-derived neurotrophic factor plays a role as an anorexigenic factor in the dorsal vagal complex. Endocrinology 146 5612–5620. 10.1210/en.2005-0419 - DOI - PubMed

[10] Bariohay B., Lebrun B., Moyse E., Jean A. (2005). Brain-derived neurotrophic factor plays a role as an anorexigenic factor in the dorsal vagal complex. Endocrinology 146 5612–5620. 10.1210/en.2005-0419 - DOI - PubMed

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

Associations of the BDNF Val66Met Polymorphism With Body Composition, Cardiometabolic Risk Factors, and Energy Intake in Youth With Obesity: Findings From the HEARTY Study

Affiliations

Associations of the BDNF Val66Met Polymorphism With Body Composition, Cardiometabolic Risk Factors, and Energy Intake in Youth With Obesity: Findings From the HEARTY Study

Authors

Affiliations

Abstract

Conflict of interest statement

Similar articles

Cited by

References

Associated data

LinkOut - more resources

Full Text Sources

Research Materials

Miscellaneous