Inflammation of the appendix in ulcerative colitis - Does it have a predictive value?

doi:10.1002/ueg2.12181

Editorial

. 2021 Dec;9(10):1107-1108.

doi: 10.1002/ueg2.12181. Epub 2021 Dec 2.

Inflammation of the appendix in ulcerative colitis - Does it have a predictive value?

Fernando Magro^{1

2

3

4}, Maria Manuela Estevinho^{1

5}, Roger Feakins⁶

Affiliations

¹ Department of Biomedicine, Unit of Pharmacology and Therapeutics, Faculty of Medicine, University of Porto, Porto, Portugal.
² Department of Gastroenterology, Centro Hospitalar São João, Porto, Portugal.
³ MedInUP, Center for Drug Discovery and Innovative Medicines, Porto, Portugal.
⁴ Unidade de Farmacologia Clínica, Centro Hospitalar Universitário de São João, Porto, Portugal.
⁵ Department of Gastroenterology, Vila Nova de Gaia/Espinho Hospital Center, Vila Nova de Gaia, Portugal.
⁶ Department of Cellular Pathology, Royal Free Hospital, London, UK.

PMID: 34855290
PMCID: PMC8672079
DOI: 10.1002/ueg2.12181

Editorial

Inflammation of the appendix in ulcerative colitis - Does it have a predictive value?

Fernando Magro et al. United European Gastroenterol J. 2021 Dec.

. 2021 Dec;9(10):1107-1108.

doi: 10.1002/ueg2.12181. Epub 2021 Dec 2.

Authors

Fernando Magro^{1

2

3

4}, Maria Manuela Estevinho^{1

5}, Roger Feakins⁶

Affiliations

¹ Department of Biomedicine, Unit of Pharmacology and Therapeutics, Faculty of Medicine, University of Porto, Porto, Portugal.
² Department of Gastroenterology, Centro Hospitalar São João, Porto, Portugal.
³ MedInUP, Center for Drug Discovery and Innovative Medicines, Porto, Portugal.
⁴ Unidade de Farmacologia Clínica, Centro Hospitalar Universitário de São João, Porto, Portugal.
⁵ Department of Gastroenterology, Vila Nova de Gaia/Espinho Hospital Center, Vila Nova de Gaia, Portugal.
⁶ Department of Cellular Pathology, Royal Free Hospital, London, UK.

PMID: 34855290
PMCID: PMC8672079
DOI: 10.1002/ueg2.12181

No abstract available

Keywords: appendix; inflammation; inflammatory bowel disease; ulcerative colitis.

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Conflict of interest statement

Fernando Magro served as speaker and received honoraria from Merck Sharp & Dohme, Abbvie, Vifor, Falk, Laboratórios Vitória, Ferring, Hospira and Biogen. Maria Manuela Estevinho and Roger Feakins have no conflict of interests to disclose.

Comment on

High prevalence of ulcerative appendicitis in patients with ulcerative colitis.
Heuthorst L, Mookhoek A, Wildenberg ME, D'Haens GR, Bemelman WA, Buskens CJ. Heuthorst L, et al. United European Gastroenterol J. 2021 Dec;9(10):1148-1156. doi: 10.1002/ueg2.12171. Epub 2021 Nov 9. United European Gastroenterol J. 2021. PMID: 34750986 Free PMC article.

Cited by

Kuicolong-yu enema decoction retains traditional Chinese medicine enema attenuates inflammatory response ulcerative colitis through TLR4/NF-κB signaling pathway.
Han L, Tang K, Fang XL, Xu JX, Mao XY, Li M. Han L, et al. World J Gastrointest Surg. 2024 Apr 27;16(4):1149-1154. doi: 10.4240/wjgs.v16.i4.1149. World J Gastrointest Surg. 2024. PMID: 38690048 Free PMC article.

References

1. Klang E, Barash Y, Soffer S, Shachar E, Lahat A. Trends in inflammatory bowel disease treatment in the past two decades‐a high‐level text mining analysis of PubMed publications. United Eur Gastroenterol J. 2021;9:1019–26. 10.1002/ueg2.12138 - DOI - PMC - PubMed
1. Parian A, Limketkai B, Koh J, Brant SR, Bitton A, Cho JH, et al. Appendectomy does not decrease the risk of future colectomy in UC: results from a large cohort and meta‐analysis. Gut. 2017;66 (8):1390–7. 10.1136/gutjnl-2016-311550 - DOI - PMC - PubMed
1. Sahami S, Kooij IA, Meijer SL, Van den Brink GR, Buskens CJ, te Velde AA. The link between the appendix and ulcerative colitis: clinical relevance and potential immunological mechanisms. Am J Gastroenterol. 2016;111(2):163–9. 10.1038/ajg.2015.301 - DOI - PubMed
1. Abdali D, Narula N. A165 Does appendectomy prevent the subsequent development of ulcerative colitis?: a systematicreview and meta‐analysis. J Can Assoc Gastroenterol. 2021;4 (Supplement_1):174–5. 10.1093/jcag/gwab002.163 - DOI
1. Stellingwerf ME, Sahami S, Winter DC, Martin ST, D’Haens GR, Cullen G, et al. Prospective cohort study of appendicectomy for treatment of therapy‐refractory ulcerative colitis. Br J Surg. 2019;106(12):1697–704. 10.1002/bjs.11259 - DOI - PubMed

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[1] Klang E, Barash Y, Soffer S, Shachar E, Lahat A. Trends in inflammatory bowel disease treatment in the past two decades‐a high‐level text mining analysis of PubMed publications. United Eur Gastroenterol J. 2021;9:1019–26. 10.1002/ueg2.12138 - DOI - PMC - PubMed

[2] Klang E, Barash Y, Soffer S, Shachar E, Lahat A. Trends in inflammatory bowel disease treatment in the past two decades‐a high‐level text mining analysis of PubMed publications. United Eur Gastroenterol J. 2021;9:1019–26. 10.1002/ueg2.12138 - DOI - PMC - PubMed

[3] Parian A, Limketkai B, Koh J, Brant SR, Bitton A, Cho JH, et al. Appendectomy does not decrease the risk of future colectomy in UC: results from a large cohort and meta‐analysis. Gut. 2017;66 (8):1390–7. 10.1136/gutjnl-2016-311550 - DOI - PMC - PubMed

[4] Parian A, Limketkai B, Koh J, Brant SR, Bitton A, Cho JH, et al. Appendectomy does not decrease the risk of future colectomy in UC: results from a large cohort and meta‐analysis. Gut. 2017;66 (8):1390–7. 10.1136/gutjnl-2016-311550 - DOI - PMC - PubMed

[5] Sahami S, Kooij IA, Meijer SL, Van den Brink GR, Buskens CJ, te Velde AA. The link between the appendix and ulcerative colitis: clinical relevance and potential immunological mechanisms. Am J Gastroenterol. 2016;111(2):163–9. 10.1038/ajg.2015.301 - DOI - PubMed

[6] Sahami S, Kooij IA, Meijer SL, Van den Brink GR, Buskens CJ, te Velde AA. The link between the appendix and ulcerative colitis: clinical relevance and potential immunological mechanisms. Am J Gastroenterol. 2016;111(2):163–9. 10.1038/ajg.2015.301 - DOI - PubMed

[7] Abdali D, Narula N. A165 Does appendectomy prevent the subsequent development of ulcerative colitis?: a systematicreview and meta‐analysis. J Can Assoc Gastroenterol. 2021;4 (Supplement_1):174–5. 10.1093/jcag/gwab002.163 - DOI

[8] Abdali D, Narula N. A165 Does appendectomy prevent the subsequent development of ulcerative colitis?: a systematicreview and meta‐analysis. J Can Assoc Gastroenterol. 2021;4 (Supplement_1):174–5. 10.1093/jcag/gwab002.163 - DOI

[9] Stellingwerf ME, Sahami S, Winter DC, Martin ST, D’Haens GR, Cullen G, et al. Prospective cohort study of appendicectomy for treatment of therapy‐refractory ulcerative colitis. Br J Surg. 2019;106(12):1697–704. 10.1002/bjs.11259 - DOI - PubMed

[10] Stellingwerf ME, Sahami S, Winter DC, Martin ST, D’Haens GR, Cullen G, et al. Prospective cohort study of appendicectomy for treatment of therapy‐refractory ulcerative colitis. Br J Surg. 2019;106(12):1697–704. 10.1002/bjs.11259 - DOI - PubMed

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Inflammation of the appendix in ulcerative colitis - Does it have a predictive value?

Affiliations

Inflammation of the appendix in ulcerative colitis - Does it have a predictive value?

Authors

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Conflict of interest statement

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