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. 2022 Dec;53(4):870-879.
doi: 10.1007/s12029-021-00769-w. Epub 2021 Nov 30.

Systemic Immune-Inflammation Index as a Prognostic Marker of Late Recurrence in Operable Gastric Cancer: a Dual-Center Study

Emre Yekedüz  1   2   3 , İzzet Dogan  4 , Dılşa Mızrak Kaya  5 , İlker Özgür  6 , Güngör Utkan  7   8 , Sezai Vatansever  4 , Salim Demirci  8   9 , Hakan Akbulut  7   8 , Yüksel Ürün  7   8
Affiliations

Systemic Immune-Inflammation Index as a Prognostic Marker of Late Recurrence in Operable Gastric Cancer: a Dual-Center Study

Emre Yekedüz et al. J Gastrointest Cancer. 2022 Dec.

Abstract

Aim: To evaluate the prognostic role of the systemic immune-inflammation index (SII) in patients with operable gastric cancer.

Methods: We assessed 354 patients with operable gastric cancer from tertiary centers in Turkey. SII was calculated by following formula: [neutrophil (cells × 109/L) × platelet (cells × 109/L)]/lymphocyte (cells × 109/L). The best cut-off value for SII was determined by using "receiver operating characteristics (ROC)" analysis. We used log-rank and Cox-regression analysis for survival analyses.

Results: One hundred twenty patients were in the late recurrence group (recurrences have developed 36 months after the surgery). SII was not a prognostic factor in the early recurrence group. However, relapse-free survival (RFS) was longer in SII-low patients than SII-high patients in the late recurrence group. In multivariable analysis, SII was the only independent prognostic factor for RFS in the late recurrence group (hazard ratio (HR): 5.42, 95% CI: 1.18-24.82, p = 0.03).

Conclusion: SII was an independent prognostic factor for RFS in GC patients with late recurrence. Late recurrence risk was higher in SII-high patients than SII-low patients. Inflammation contributes to tumor progression, invasion, and metastasis. Prolonged exposure to chronic inflammation could explain the results of this study.

Keywords: Gastric cancer; Prognosis; Systemic immune-inflammation index.

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