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Review
. 2021 Nov 4:9:768309.
doi: 10.3389/fcell.2021.768309. eCollection 2021.

Septin Remodeling During Mammalian Cytokinesis

Giulia Russo  1 , Michael Krauss  1
Affiliations
Review

Septin Remodeling During Mammalian Cytokinesis

Giulia Russo et al. Front Cell Dev Biol. .

Abstract

Cytokinesis mediates the final separation of a mother cell into two daughter cells. Septins are recruited to the cleavage furrow at an early stage. During cytokinetic progression the septin cytoskeleton is constantly rearranged, ultimately leading to a concentration of septins within the intercellular bridge (ICB), and to the formation of two rings adjacent to the midbody that aid ESCRT-dependent abscission. The molecular mechanisms underlying this behavior are poorly understood. Based on observations that septins can associate with actin, microtubules and associated motors, we review here established roles of septins in mammalian cytokinesis, and discuss, how septins may support cytokinetic progression by exerting their functions at particular sites. Finally, we discuss how this might be assisted by phosphoinositide-metabolizing enzymes.

Keywords: actomyosin; cytokinesis; microtubules; phosphoinositides; septins.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

FIGURE 1
FIGURE 1
Septins during cytokinesis. (A) At anaphase RhoA is activated at the midzone (red shadow). (B) At early telophase septins (green) are recruited to furrow by anillin (pink), and during furrow constriction promote extrusion of plasma membrane tubules. (C) After ingression septins reorganize into a double ring and support the formation of secondary ingression sites by dictating the relocalization of anillin and actomyosin (purple). At the same time SEPT9 locally activates Tsg101 (light blue). Initial recruitment of ESCRTI to the midbody is not depicted for clarity reasons. (D) Recruitment of ESCRTIII (red) occurs concomitantly with the disappearance of septin double rings. PI(4,5)P2 (dark grey) builds up early at the cleavage furrow, and might also become concentrated at the midbody ring. PI(4,5)P2 is hydrolyzed upon arrival of OCRL (blue) at the ICB. Prior to abscission a pool of PI(3)P (yellow) is generated at the midbody that likely supports ESCRT assembly.
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