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Case Reports
. 2021 Nov 12:2021:3513223.
doi: 10.1155/2021/3513223. eCollection 2021.

CMV-Related Gastric Ulcer and Gastroduodenitis in an Immunocompetent Patient: A Case Report and Literature Review

Andrawus Beany  1   2 , Tova Rainis  1   2
Affiliations
Case Reports

CMV-Related Gastric Ulcer and Gastroduodenitis in an Immunocompetent Patient: A Case Report and Literature Review

Andrawus Beany et al. Case Rep Gastrointest Med. .

Abstract

Background: Cytomegalovirus (CMV)- related gastroduodenal infection is rare in immunocompetent hosts, and although it is considered a self-limiting condition in most cases, there is scarce literature to assert its management. Case Presentation. We report a case of a 66-year-old immunocompetent male patient diagnosed with a giant gastric ulcer caused by CMV infection. The ulcer manifested as refractory vomiting and melena. Rapid and full resolution was observed on proton-pump inhibitor (PPI) monotherapy.

Conclusion: Gastric CMV infection might mimic an advanced gastric tumor in individuals with an intact immune system. The condition is rare, and the diagnosis is challenging and oftentimes overlooked. However, a rapid resolution has been documented in all cases, even without antiviral therapy.

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Conflict of interest statement

The authors declare that they have no conflicts of interest.

Figures

Figure 1
Figure 1
Endoscopy showing the gastric ulcer.
Figure 2
Figure 2
Computed tomography showing antral-wall thickening and mesenteric lymphadenopathy (arrow).
Figure 3
Figure 3
The patient's histological findings. (a) H&E staining showing chronic gastritis and scattered large cells with intranuclear and intracytoplasmatic inclusion bodies (arrows); (b) positive IHC in a representative duodenal specimen; (c) H&E staining showing duodenitis and large cells with inclusion bodies (arrow).
Figure 4
Figure 4
Follow-up endoscopy showing a residual scar.
See this image and copyright information in PMC

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