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Meta-Analysis
. 2021 Nov 3:12:696106.
doi: 10.3389/fendo.2021.696106. eCollection 2021.

Animal Toxicology Studies on the Male Reproductive Effects of 2,3,7,8-Tetrachlorodibenzo-p-Dioxin: Data Analysis and Health Effects Evaluation

Tongtong Zhang  1 , Xiang Zhou  1 , Xiaohan Ren  1 , Xu Zhang  1 , Jiajin Wu  1 , Shangqian Wang  1   2 , Zengjun Wang  1   3
Affiliations
Meta-Analysis

Animal Toxicology Studies on the Male Reproductive Effects of 2,3,7,8-Tetrachlorodibenzo-p-Dioxin: Data Analysis and Health Effects Evaluation

Tongtong Zhang et al. Front Endocrinol (Lausanne). .

Abstract

2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is a well-known environmental poison that exist in the environment for many years. However, its effect on the male reproductive system has not been clearly stated. We conducted a meta-analysis of the effect of TCDD on the male reproductive system of rodents about TCDD. Results showed that that TCDD exposure reduced the testis weight (weighted mean difference [WMD]: -0.035, 95% confidence interval [CI]: -0.046 to -0.025), sperm count (WMD: -35, 95% CI: -42.980 to -27.019), and blood testosterone concentration (WMD: -0.171, 95% CI: -0.269 to -0.073). According to our research results, TCDD can cause damage to the male reproductive system of rodents through direct or indirect exposure. In order to further explore the potential hazards of TCDD to humans, more human-related research needs to be carried out.

Keywords: dioxin; environmental pollutant; meta-analysis; reproductive toxicity; semen parameter.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Study selection.
Figure 2
Figure 2
Forest plots of overall effects. Overall effects of TCDD and (A) sperm count (×10⁶), (B) daily sperm production (×10⁶), and (C) serum testosterone (ng/ml); (D) Total effect of TCDD and ventral prostate weight (g).
Figure 3
Figure 3
Holistic view of TCDD environmental exposure and drug remedy.
See this image and copyright information in PMC

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