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Review
. 2021 Oct 25;17(15):4493-4513.
doi: 10.7150/ijbs.66181. eCollection 2021.

Close interactions between lncRNAs, lipid metabolism and ferroptosis in cancer

Jingjing Huang  1   2 , Jin Wang  3 , Hua He  1   2 , Zichen Huang  3 , Sufang Wu  1   2 , Chao Chen  3 , Wenbing Liu  4 , Li Xie  4 , Yongguang Tao  5 , Li Cong  1   2 , Yiqun Jiang  1   2
Affiliations
Review

Close interactions between lncRNAs, lipid metabolism and ferroptosis in cancer

Jingjing Huang et al. Int J Biol Sci. .

Abstract

Abnormal lipid metabolism including synthesis, uptake, modification, degradation and transport has been considered a hallmark of malignant tumors and contributes to the supply of substances and energy for rapid cell growth. Meanwhile, abnormal lipid metabolism is also associated with lipid peroxidation, which plays an important role in a newly discovered type of regulated cell death termed ferroptosis. Long noncoding RNAs (lncRNAs) have been proven to be associated with the occurrence and progression of cancer. Growing evidence indicates that lncRNAs are key regulators of abnormal lipid metabolism and ferroptosis in cancer. In this review, we mainly summarized the mechanism by which lncRNAs regulate aberrant lipid metabolism in cancer, illustrated that lipid metabolism can also influence the expression of lncRNAs, and discussed the mechanism by which lncRNAs affect ferroptosis. A comprehensive understanding of the interactions between lncRNAs, lipid metabolism and ferroptosis could help us to develop novel strategies for precise cancer treatment in the future.

Keywords: Cancer; Ferroptosis; Lipid metabolism; LncRNAs.

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Conflict of interest statement

Competing Interests: The authors have declared that no competing interest exists.

Figures

Figure 1
Figure 1
The known functions of lncRNAs in tumor lipid metabolism. The main lipids in tumor lipid metabolism include cholesterol, FAs, TG and PL. LncRNAs regulate the synthesis and catabolism of these four types of lipids through a variety of mechanisms, thereby participating in the occurrence and development of cancer.
Figure 2
Figure 2
Lipid metabolism regulates the occurrence and development of tumors by regulating lncRNAs. Lipid metabolites and enzymes involved in lipid metabolism can in turn regulate the expression of lncRNAs to participate in tumor progression. For example, cholesterol regulates lncRNA HULC to promote liver cancer progression, palmitic acid regulates lncRNA UCA1 to promote gastric cancer metastasis, and PLD regulates lncRNA ANRIL to exert an anti-large cell lung cancer effect.
Figure 3
Figure 3
The metabolic pathway of lncRNAs regulating ferroptosis. Lipid peroxides play a key role in initiating ferroptosis. LncRNAs participate in the occurrence of ferroptosis in tumors by regulating related genes involved in lipid peroxide accumulation.
See this image and copyright information in PMC

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