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. 2021 Nov;43 Suppl 2(Suppl 2):S54-S63.
doi: 10.1016/j.htct.2021.09.008.

Associação Brasileira de Hematologia, Hemoterapia e Terapia Celular Consensus on genetically modified cells. VIII: CAR-T cells: preclinical development - Safety and efficacy evaluation

Virginia Picanço-Castro  1 , Martín Hernan Bonamino  2 , Rodrigo Nalio Ramos  3 , Renato L Guerino-Cunha  4 , Theo Gremen M Oliveira  5 , Eduardo M Rego  6
Affiliations

Associação Brasileira de Hematologia, Hemoterapia e Terapia Celular Consensus on genetically modified cells. VIII: CAR-T cells: preclinical development - Safety and efficacy evaluation

Virginia Picanço-Castro et al. Hematol Transfus Cell Ther. 2021 Nov.

Abstract

Currently, there are four CAR-T products commercially available on the market. CAR-T cells have shown high remission rates and they represent an effective treatment option for patients with resistant or refractory B cell malignancies. Approval of these cell therapy products came after an extended period of preclinical evaluation that demonstrated unprecedented efficacy in this difficult-to-treat patient population. This review article outlines the main preclinical evaluations needed for CAR T cell product development.

Keywords: Adoptive cell therapy; Advanced cell therapy; Chimeric antigen receptor; Immunotherapy; Preclinical studies.

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Conflict of interest statement

Conflicts of interest The authors declare no conflicts of interest.

Figures

Fig. 1
Figure 1
Production of CAR T cells in a GMP facility.
Fig. 2
Figure 2
Description of CD8+ T cell states of differentiation (Gattinoni and collaborators).
See this image and copyright information in PMC

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