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. 2021 Nov 8:2021:6366914.
doi: 10.1155/2021/6366914. eCollection 2021.

Clinical Effects of Integrated Traditional Chinese and Western Medicine in Treating Severe Preeclampsia and Its Influence on Maternal and Infant Outcomes after Cesarean Section under Combined Lumbar and Epidural Anesthesia

Xiaolu Wang  1 , Wenpeng Wei  2 , Yanyan Qi  3 , Lihua Dong  4 , Yun Zhang  5
Affiliations

Clinical Effects of Integrated Traditional Chinese and Western Medicine in Treating Severe Preeclampsia and Its Influence on Maternal and Infant Outcomes after Cesarean Section under Combined Lumbar and Epidural Anesthesia

Xiaolu Wang et al. Evid Based Complement Alternat Med. .

Abstract

Objective: This study is aimed to observe the clinical effects of integrated traditional Chinese and Western medicine in treating severe preeclampsia (SPE) and its effects on maternal and infant outcomes after cesarean section under combined lumbar and epidural anesthesia.

Method: One hundred and sixty-six pregnant women with SPE were randomly divided into an experimental group and control group, with 83 cases in each group. The control group was given conventional treatments such as magnesium sulfate, and the experimental group received self-made traditional Chinese medicine decoction for oral administration.

Results: The total clinical effective rate of treatment in the experimental group was significantly higher than that in the control group. After treatment, the systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial pressure (MAP), and 24 h proteinuria (24 h PRO) levels of the experimental group were significantly lower than those of the control group. After cesarean section (c-section) under combined lumbar and epidural anesthesia, there were statistically significant differences in placental abruption, uterine weakness, fetal intrauterine distress, and neonatal asphyxia in the experimental group, while there were no significant differences in oligohydramnios. After treatment, the contents of inflammatory factors in both groups decreased, and the decrease was more prominent in the experimental group. After treatment, the levels of blood urea nitrogen (BUN), serum creatinine (Scr), and albumin (Alb) and β2 microglobulin (β2-MG) of the two groups of patients decreased, and the levels of them in the experimental group decreased. After treatment, the levels of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) in the two groups increased. However, the levels of malondialdehyde (MDA), lipid peroxide (LPO), and advanced oxidation protein products (AOPP) all reduced, and the increase or decrease in the experimental group was more prominent.

Conclusion: The combination of traditional Chinese and Western medicine can reduce the blood pressure of a patient with SPE. After the combined spinal-epidural anesthesia and cesarean section, it can significantly improve the maternal and infant outcomes and renal function, reduce inflammatory factors levels and body oxidative stress, and increase the activities of antioxidant enzymes.

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Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Figure 1
Figure 1
Comparison of blood pressure, MAP, and 24 h PRO content between the two groups of patients after treatment. (a) The comparison of SBP after treatment of the two groups of patients. (b) The comparison of DBP after treatment of the two groups of patients. (c) The comparison of the MAP between the two groups of patients after treatment. (d) The comparison of PRO content of the two groups of patients at 24 h after treatment.
Figure 2
Figure 2
Comparison of serum inflammatory factor levels before and after treatment between the two groups. (a) The comparison of Hcy levels between the two groups of patients before and after treatment. (b) The comparison of CRP levels between the two groups of patients before and after treatment. (c) The comparison of IL-6 levels before and after treatment in the two groups of patients. (d) The comparison of TNF-α levels before and after treatment in the two groups.
Figure 3
Figure 3
Comparison of renal function indexes of the two groups of patients before and after treatment. (a) The comparison of BUN levels between the two groups of patients before and after treatment. (b) The comparison of Scr levels between the two groups of patients before and after treatment. (c) The comparison of Alb levels between the two groups of patients before and after treatment. (d) The comparison of β2-MG levels before and after treatment in the two groups.
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