Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2022 Apr;97(2):604-614.
doi: 10.1111/brv.12814. Epub 2021 Nov 15.

Mechanosensing by Piezo1 and its implications for physiology and various pathologies

Austin Lai  1 , Charles D Cox  2 , Nadia Chandra Sekar  1 , Peter Thurgood  3 , Anthony Jaworowski  1 , Karlheinz Peter  1   4   5 , Sara Baratchi  1   4   5
Affiliations
Review

Mechanosensing by Piezo1 and its implications for physiology and various pathologies

Austin Lai et al. Biol Rev Camb Philos Soc. 2022 Apr.

Abstract

Piezo1 is a mechanosensitive ion channel with essential roles in cardiovascular, lung, urinary, and immune functions. Piezo1 is widely distributed in different tissues in the human body and its specific roles have been identified following a decade of research; however, not all are well understood. Many structural and functional characteristics of Piezo1 have been discovered and are known to differ greatly from the characteristics of other mechanosensitive ion channels. Understanding the mechanisms by which this ion channel functions may be useful in determining its physiological roles in various organ systems. This review provides insight into the signalling pathways activated by mechanical stimulation of Piezo1 in various organ systems and cell types. We discuss downstream targets of Piezo1 and the overall effects resulting from Piezo1 activation, which may provide insights into potential treatment targets for diseases involving this ion channel.

Keywords: Piezo1; mechanoreceptor; mechanosensitive ion channel; mechanotransduction; shear stress.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Albarran-Juarez, J., Iring, A., Wang, S., Joseph, S., Grimm, M., Strilic, B., Wettschureck, N., Althoff, T. F. & Offermanns, S. (2018). Piezo1 and Gq/G11 promote endothelial inflammation depending on flow pattern and integrin activation. Journal of Experimental Medicine 215(10), 2655-2672.
    1. Alves, M., Beamer, E. & Engel, T. (2018). The metabotropic purinergic P2Y receptor family as novel drug target in epilepsy. Frontiers in Pharmacology 9, 193.
    1. Bae, C., Gnanasambandam, R., Nicolai, C., Sachs, F. & Gottlieb, P. A. (2013). Xerocytosis is caused by mutations that alter the kinetics of the mechanosensitive channel PIEZO1. Procedings of the National Academy of Sciences USA 110(12), E1162-E1168.
    1. Bae, C., Suchyna, T. M., Ziegler, L., Sachs, F. & Gottlieb, P. A. (2016). Human PIEZO1 ion channel functions as a split protein. PLoS One 11(3), e0151289.
    1. Baeriswyl, D. C., Prionisti, I., Peach, T., Tsolkas, G., Chooi, K. Y., Vardakis, J., Morel, S., Diagbouga, M. R., Bijlenga, P., Cuhlmann, S., Evans, P., Kwak, B. R., Ventikos, Y. & Krams, R. (2019). Disturbed flow induces a sustained, stochastic NF-κB activation which may support intracranial aneurysm growth in vivo. Scientific Reports 9(1), 4738.

Publication types

LinkOut - more resources