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. 2021 Oct 29:9:659137.
doi: 10.3389/fped.2021.659137. eCollection 2021.

A Meta-Analysis of the Risk Factors of Persistent Pulmonary Hypertension in Newborns

Ran Zhou  1 , You-Ning Zheng  1 , Xin-Ying Zhang  1 , Ya-Ying Cheng  1
Affiliations

A Meta-Analysis of the Risk Factors of Persistent Pulmonary Hypertension in Newborns

Ran Zhou et al. Front Pediatr. .

Abstract

Objective: To determine the risk factors of persistent pulmonary hypertension of the newborn using a meta-analysis method and provide a reference for its clinical prevention and treatment. Methods: A meta-analysis was performed by searching the PubMed, Embase, Cochrane Library, China Biology Medicine Disc, Wanfang, and Chinese VIP journal databases, as well as the China National Knowledge Infrastructure. Results: A total of 22 references were included in the meta-analysis; the cumulative medical records comprised 7,937 cases, and 2,613,072 control cases were included. A total of 12 related risk factors were included (7 were associated with pregnant women and 5 were associated with newborns). Conclusion: Among the 12 associated risk factors included, the three most important and their combined odds ratio values and 95% CI were as follows: (1) pregnant women smoking, 4.85 (1.98-11.9) during pregnancy; (2) gestational weeks <37, 4.34 (1.64-11.5); (3) perinatal asphyxia, 3.9 (2.87-5.31).

Keywords: case control study; meta-analysis; newborn; pulmonary hypertension; risk factors.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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The literature screening flow chart.
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