Molecular Mechanisms of Mesenchymal Stem Cell-Based Therapy in Acute Kidney Injury

doi:10.3390/ijms222111406

Review

. 2021 Oct 22;22(21):11406.

doi: 10.3390/ijms222111406.

Molecular Mechanisms of Mesenchymal Stem Cell-Based Therapy in Acute Kidney Injury

Pei-Wen Lee^{1

2}, Bo-Sheng Wu^{1

3}, Chih-Yu Yang^{1

3

4

5

6}, Oscar Kuang-Sheng Lee^{1

3

6

7}

Affiliations

¹ Institute of Clinical Medicine, School of Medicine, National Yang Ming Chiao Tung University, Taipei 11221, Taiwan.
² Hong Deh Clinic, Taipei 11251, Taiwan.
³ Faculty of Medicine, School of Medicine, National Yang Ming Chiao Tung University, Taipei 11221, Taiwan.
⁴ Department of Medicine, Division of Nephrology, Taipei Veterans General Hospital, Taipei 11217, Taiwan.
⁵ Center for Intelligent Drug Systems and Smart Bio-Devices (IDS2B), National Yang Ming Chiao Tung University, Hsinchu 30010, Taiwan.
⁶ Stem Cell Research Center, National Yang Ming Chiao Tung University, Taipei 11221, Taiwan.
⁷ Department of Orthopedics, China Medical University Hospital, Taichung 40447, Taiwan.

PMID: 34768837
PMCID: PMC8583897
DOI: 10.3390/ijms222111406

Review

Molecular Mechanisms of Mesenchymal Stem Cell-Based Therapy in Acute Kidney Injury

Pei-Wen Lee et al. Int J Mol Sci. 2021.

. 2021 Oct 22;22(21):11406.

doi: 10.3390/ijms222111406.

Authors

Pei-Wen Lee^{1

2}, Bo-Sheng Wu^{1

3}, Chih-Yu Yang^{1

3

4

5

6}, Oscar Kuang-Sheng Lee^{1

3

6

7}

Affiliations

¹ Institute of Clinical Medicine, School of Medicine, National Yang Ming Chiao Tung University, Taipei 11221, Taiwan.
² Hong Deh Clinic, Taipei 11251, Taiwan.
³ Faculty of Medicine, School of Medicine, National Yang Ming Chiao Tung University, Taipei 11221, Taiwan.
⁴ Department of Medicine, Division of Nephrology, Taipei Veterans General Hospital, Taipei 11217, Taiwan.
⁵ Center for Intelligent Drug Systems and Smart Bio-Devices (IDS2B), National Yang Ming Chiao Tung University, Hsinchu 30010, Taiwan.
⁶ Stem Cell Research Center, National Yang Ming Chiao Tung University, Taipei 11221, Taiwan.
⁷ Department of Orthopedics, China Medical University Hospital, Taichung 40447, Taiwan.

PMID: 34768837
PMCID: PMC8583897
DOI: 10.3390/ijms222111406

Abstract

Acute kidney injury (AKI) causes a lot of harm to human health but is treated by only supportive therapy in most cases. Recent evidence shows that mesenchymal stem cells (MSCs) benefit kidney regeneration through releasing paracrine factors and extracellular vesicles (EVs) to the recipient kidney cells and are considered to be promising cellular therapy for AKI. To develop more efficient, precise therapies for AKI, we review the therapeutic mechanism of MSCs and MSC-derived EVs in AKI and look for a better understanding of molecular signaling and cellular communication between donor MSCs and recipient kidney cells. We also review recent clinical trials of MSC-EVs in AKI. This review summarizes the molecular mechanisms of MSCs' therapeutic effects on kidney regeneration, expecting to comprehensively facilitate future clinical application for treating AKI.

Keywords: acute kidney injury; extracellular vesicles; mesenchymal stem cells.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

**Figure 1**
Schematic representation of the kidney regeneration by mesenchymal stem cell-derived extracellular vesicles in acute kidney injury. Abbreviations: ADSC, adipose-derived mesenchymal stem cell; BM-MSC, bone marrow-derived mesenchymal stem cell; FM-MSC, fetal membrane-derived MSCs; iPSC-MSCs, induced pluripotent stem cell-derived MSCs; ucMSC, umbilical cord-derived mesenchymal stem cell; KMSC, kidney-derived mesenchymal stem cell; LSC, liver stem cell.

See this image and copyright information in PMC

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References

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1. Chertow G.M., Burdick E., Honour M., Bonventre J.V., Bates D.W. Acute kidney injury, mortality, length of stay, and costs in hospitalized patients. J. Am. Soc. Nephrol. 2005;16:3365–3370. doi: 10.1681/ASN.2004090740. - DOI - PubMed
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[1] Lozano R., Naghavi M., Foreman K., Lim S., Shibuya K., Aboyans V., Abraham J., Adair T., Aggarwal R., Ahn S.Y. Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: A systematic analysis for the Global Burden of Disease Study 2010. Lancet. 2012;380:2095–2128. doi: 10.1016/S0140-6736(12)61728-0. - DOI - PMC - PubMed

[2] Lozano R., Naghavi M., Foreman K., Lim S., Shibuya K., Aboyans V., Abraham J., Adair T., Aggarwal R., Ahn S.Y. Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: A systematic analysis for the Global Burden of Disease Study 2010. Lancet. 2012;380:2095–2128. doi: 10.1016/S0140-6736(12)61728-0. - DOI - PMC - PubMed

[3] Uchino S., Kellum J.A., Bellomo R. Acute renal failure in critically ill patients: A multinational, multicenter study. JAMA. 2005;294:813–818. doi: 10.1001/jama.294.7.813. - DOI - PubMed

[4] Uchino S., Kellum J.A., Bellomo R. Acute renal failure in critically ill patients: A multinational, multicenter study. JAMA. 2005;294:813–818. doi: 10.1001/jama.294.7.813. - DOI - PubMed

[5] Chertow G.M., Burdick E., Honour M., Bonventre J.V., Bates D.W. Acute kidney injury, mortality, length of stay, and costs in hospitalized patients. J. Am. Soc. Nephrol. 2005;16:3365–3370. doi: 10.1681/ASN.2004090740. - DOI - PubMed

[6] Chertow G.M., Burdick E., Honour M., Bonventre J.V., Bates D.W. Acute kidney injury, mortality, length of stay, and costs in hospitalized patients. J. Am. Soc. Nephrol. 2005;16:3365–3370. doi: 10.1681/ASN.2004090740. - DOI - PubMed

[7] Basile D.P., Anderson M.D., Sutton T.A. Pathophysiology of acute kidney injury. Compr. Physiol. 2012;2:1303–1353. doi: 10.1002/cphy.c110041. - DOI - PMC - PubMed

[8] Basile D.P., Anderson M.D., Sutton T.A. Pathophysiology of acute kidney injury. Compr. Physiol. 2012;2:1303–1353. doi: 10.1002/cphy.c110041. - DOI - PMC - PubMed

[9] Chawla L.S., Kimmel P.L. Acute kidney injury and chronic kidney disease: An integrated clinical syndrome. Kidney Int. 2012;82:516–524. doi: 10.1038/ki.2012.208. - DOI - PubMed

[10] Chawla L.S., Kimmel P.L. Acute kidney injury and chronic kidney disease: An integrated clinical syndrome. Kidney Int. 2012;82:516–524. doi: 10.1038/ki.2012.208. - DOI - PubMed

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Molecular Mechanisms of Mesenchymal Stem Cell-Based Therapy in Acute Kidney Injury

Affiliations

Molecular Mechanisms of Mesenchymal Stem Cell-Based Therapy in Acute Kidney Injury

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Affiliations

Abstract

Conflict of interest statement

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Abstract

Conflict of interest statement

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